Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery

Linear peptides can mimic and disrupt protein-protein interactions involved in critical cell signaling pathways. Such peptides however are usually protease sensitive and unable to engage with intracellular targets due to lack of membrane permeability. Peptide stapling has been proposed to circumvent...

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Detalles Bibliográficos
Autores principales: Thean, D., Ebo, J. S., Luxton, T., Lee, Xue’Er Cheryl, Yuen, T. Y., Ferrer, F. J., Johannes, C. W., Lane, D. P., Brown, C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431883/
https://www.ncbi.nlm.nih.gov/pubmed/28496125
http://dx.doi.org/10.1038/s41598-017-01712-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431883/
https://www.ncbi.nlm.nih.gov/pubmed/28496125
http://dx.doi.org/10.1038/s41598-017-01712-5

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