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Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Bryostatin is in clinical trials for Alzheimer’s disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the...

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Detalles Bibliográficos
Autores principales:	Ryckbosch, Steven M., Wender, Paul A., Pande, Vijay S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431895/ https://www.ncbi.nlm.nih.gov/pubmed/28232750 http://dx.doi.org/10.1038/s41467-016-0015-8

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