Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintain...

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Detalles Bibliográficos
Autores principales: Rodrigues, Tiago, Matafome, Paulo, Sereno, José, Almeida, José, Castelhano, João, Gamas, Luís, Neves, Christian, Gonçalves, Sónia, Carvalho, Catarina, Arslanagic, Amina, Wilcken, Elinor, Fonseca, Rita, Simões, Ilda, Conde, Silvia Vilares, Castelo-Branco, Miguel, Seiça, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431896/
https://www.ncbi.nlm.nih.gov/pubmed/28490763
http://dx.doi.org/10.1038/s41598-017-01730-3

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