Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2

Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. NF-E2 related factor-2 (Nrf2), a master regulator of antioxida...

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Detalles Bibliográficos
Autores principales: Karathedath, Sreeja, Rajamani, Bharathi M., Musheer Aalam, Syed Mohammed, Abraham, Ajay, Varatharajan, Savitha, Krishnamurthy, Partha, Mathews, Vikram, Velayudhan, Shaji Ramachandran, Balasubramanian, Poonkuzhali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432104/
https://www.ncbi.nlm.nih.gov/pubmed/28505160
http://dx.doi.org/10.1371/journal.pone.0177227

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