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Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

BRCA1 plays a critical role in homology-directed repair (HDR) of DNA double strand breaks, and the repair defect of BRCA1-mutant cancer cells is being targeted with platinum drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. We have employed relatively simple and sensitive assays to determine...

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Detalles Bibliográficos
Autores principales:	Anantha, Rachel W, Simhadri, Srilatha, Foo, Tzeh Keong, Miao, Susanna, Liu, Jingmei, Shen, Zhiyuan, Ganesan, Shridar, Xia, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432210/ https://www.ncbi.nlm.nih.gov/pubmed/28398198 http://dx.doi.org/10.7554/eLife.21350

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