Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer

Acid-sensing ion channels 1a (ASIC1a) has been reported to promote migration and invasion in liver cancer. However, the clinical significance and molecular mechanism of ASIC1a in liver cancer remain unknown. In the study, we found that ASIC1a is frequently up-regulated in liver cancer tissues. The o...

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Autores principales: Jin, Cheng, Yuan, Feng-Lai, Gu, Yuan-Long, Li, Xia, Liu, Min-Feng, Shen, Xiao-Min, Liu, Bo, Zhu, Mao-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432231/
https://www.ncbi.nlm.nih.gov/pubmed/27462920
http://dx.doi.org/10.18632/oncotarget.10774
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author Jin, Cheng
Yuan, Feng-Lai
Gu, Yuan-Long
Li, Xia
Liu, Min-Feng
Shen, Xiao-Min
Liu, Bo
Zhu, Mao-Qun
author_facet Jin, Cheng
Yuan, Feng-Lai
Gu, Yuan-Long
Li, Xia
Liu, Min-Feng
Shen, Xiao-Min
Liu, Bo
Zhu, Mao-Qun
author_sort Jin, Cheng
collection PubMed
description Acid-sensing ion channels 1a (ASIC1a) has been reported to promote migration and invasion in liver cancer. However, the clinical significance and molecular mechanism of ASIC1a in liver cancer remain unknown. In the study, we found that ASIC1a is frequently up-regulated in liver cancer tissues. The over-expression of ASIC1a is associated with advanced clinical stage and poor prognosis. The pro-proliferative of ASIC1a is pH dependent. Knockout of ASIC1a by CRISPR/CAS9 inhibited liver cancer cell proliferation and tumorigenicity in vitro and in vivo through β-catenin degradation and LEF-TCF inactivation. Our results indicated a potential diagnostic marker and chemotherapeutic target for liver cancer.
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spelling pubmed-54322312017-05-17 Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer Jin, Cheng Yuan, Feng-Lai Gu, Yuan-Long Li, Xia Liu, Min-Feng Shen, Xiao-Min Liu, Bo Zhu, Mao-Qun Oncotarget Research Paper Acid-sensing ion channels 1a (ASIC1a) has been reported to promote migration and invasion in liver cancer. However, the clinical significance and molecular mechanism of ASIC1a in liver cancer remain unknown. In the study, we found that ASIC1a is frequently up-regulated in liver cancer tissues. The over-expression of ASIC1a is associated with advanced clinical stage and poor prognosis. The pro-proliferative of ASIC1a is pH dependent. Knockout of ASIC1a by CRISPR/CAS9 inhibited liver cancer cell proliferation and tumorigenicity in vitro and in vivo through β-catenin degradation and LEF-TCF inactivation. Our results indicated a potential diagnostic marker and chemotherapeutic target for liver cancer. Impact Journals LLC 2016-07-22 /pmc/articles/PMC5432231/ /pubmed/27462920 http://dx.doi.org/10.18632/oncotarget.10774 Text en Copyright: © 2017 Jin et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Jin, Cheng
Yuan, Feng-Lai
Gu, Yuan-Long
Li, Xia
Liu, Min-Feng
Shen, Xiao-Min
Liu, Bo
Zhu, Mao-Qun
Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title_full Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title_fullStr Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title_full_unstemmed Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title_short Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer
title_sort over-expression of asic1a promotes proliferation via activation of the β-catenin/lef-tcf axis and is associated with disease outcome in liver cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432231/
https://www.ncbi.nlm.nih.gov/pubmed/27462920
http://dx.doi.org/10.18632/oncotarget.10774
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