Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance

Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SA...

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Autores principales: Jeitany, Maya, Bakhos-Douaihy, Dalal, Silvestre, David C., Pineda, Jose R., Ugolin, Nicolas, Moussa, Angela, Gauthier, Laurent R., Busso, Didier, Junier, Marie-Pierre, Chneiweiss, Hervé, Chevillard, Sylvie, Desmaze, Chantal, Boussin, François D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432255/
https://www.ncbi.nlm.nih.gov/pubmed/28412741
http://dx.doi.org/10.18632/oncotarget.15447
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author Jeitany, Maya
Bakhos-Douaihy, Dalal
Silvestre, David C.
Pineda, Jose R.
Ugolin, Nicolas
Moussa, Angela
Gauthier, Laurent R.
Busso, Didier
Junier, Marie-Pierre
Chneiweiss, Hervé
Chevillard, Sylvie
Desmaze, Chantal
Boussin, François D.
author_facet Jeitany, Maya
Bakhos-Douaihy, Dalal
Silvestre, David C.
Pineda, Jose R.
Ugolin, Nicolas
Moussa, Angela
Gauthier, Laurent R.
Busso, Didier
Junier, Marie-Pierre
Chneiweiss, Hervé
Chevillard, Sylvie
Desmaze, Chantal
Boussin, François D.
author_sort Jeitany, Maya
collection PubMed
description Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.
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spelling pubmed-54322552017-05-17 Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance Jeitany, Maya Bakhos-Douaihy, Dalal Silvestre, David C. Pineda, Jose R. Ugolin, Nicolas Moussa, Angela Gauthier, Laurent R. Busso, Didier Junier, Marie-Pierre Chneiweiss, Hervé Chevillard, Sylvie Desmaze, Chantal Boussin, François D. Oncotarget Research Paper Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells. Impact Journals LLC 2017-02-17 /pmc/articles/PMC5432255/ /pubmed/28412741 http://dx.doi.org/10.18632/oncotarget.15447 Text en Copyright: © 2017 Jeitany et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Jeitany, Maya
Bakhos-Douaihy, Dalal
Silvestre, David C.
Pineda, Jose R.
Ugolin, Nicolas
Moussa, Angela
Gauthier, Laurent R.
Busso, Didier
Junier, Marie-Pierre
Chneiweiss, Hervé
Chevillard, Sylvie
Desmaze, Chantal
Boussin, François D.
Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title_full Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title_fullStr Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title_full_unstemmed Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title_short Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
title_sort opposite effects of gcn5 and pcaf knockdowns on the alternative mechanism of telomere maintenance
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432255/
https://www.ncbi.nlm.nih.gov/pubmed/28412741
http://dx.doi.org/10.18632/oncotarget.15447
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