Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation

Fms-like tyrosine kinase 3 (FLT3) with internal tandem duplications (ITD) is a major oncoprotein in acute myeloid leukemia (AML), and confers an unfavorable prognosis. Interference with FLT3ITD signaling is therefore pursued as a promising therapeutic strategy. In this study we show that abrogation...

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Detalles Bibliográficos
Autores principales: Tsitsipatis, Dimitrios, Jayavelu, Ashok Kumar, Müller, Jörg P., Bauer, Reinhard, Schmidt-Arras, Dirk, Mahboobi, Siavosh, Schnöder, Tina M., Heidel, Florian, Böhmer, Frank-D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432283/
https://www.ncbi.nlm.nih.gov/pubmed/28460451
http://dx.doi.org/10.18632/oncotarget.15772

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