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TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polym...

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Autores principales: Chen, Bang-Dang, Chen, Xiao-Cui, Pan, Shuo, Yang, Yi-Ning, He, Chun-Hui, Liu, Fen, Ma, Xiang, Gai, Min-Tao, Ma, Yi-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432307/
https://www.ncbi.nlm.nih.gov/pubmed/28460474
http://dx.doi.org/10.18632/oncotarget.15851
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author Chen, Bang-Dang
Chen, Xiao-Cui
Pan, Shuo
Yang, Yi-Ning
He, Chun-Hui
Liu, Fen
Ma, Xiang
Gai, Min-Tao
Ma, Yi-Tong
author_facet Chen, Bang-Dang
Chen, Xiao-Cui
Pan, Shuo
Yang, Yi-Ning
He, Chun-Hui
Liu, Fen
Ma, Xiang
Gai, Min-Tao
Ma, Yi-Tong
author_sort Chen, Bang-Dang
collection PubMed
description The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Data were analyzed for two separate groups: men and women. For rs2941484, the genotype distribution frequency in hyperuricemic subjects and was significantly different from that in normouricemic controls in men (P = 0.038). Meanwhile, in recessive model of rs2941484, the distribution frequency of TT genotype and CC+CT genotypes also differed significantly between the hyperuricemia men and normouricemic men (P = 0.011). For the other 3 SNPs in both men and women, there was no difference in the genotype and allele and distribution frequency between the hyperuricemia patients and normouricemic controls. In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001). Therefore, TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men.
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spelling pubmed-54323072017-05-17 TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men Chen, Bang-Dang Chen, Xiao-Cui Pan, Shuo Yang, Yi-Ning He, Chun-Hui Liu, Fen Ma, Xiang Gai, Min-Tao Ma, Yi-Tong Oncotarget Research Paper The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941484, rs4735692). Data were analyzed for two separate groups: men and women. For rs2941484, the genotype distribution frequency in hyperuricemic subjects and was significantly different from that in normouricemic controls in men (P = 0.038). Meanwhile, in recessive model of rs2941484, the distribution frequency of TT genotype and CC+CT genotypes also differed significantly between the hyperuricemia men and normouricemic men (P = 0.011). For the other 3 SNPs in both men and women, there was no difference in the genotype and allele and distribution frequency between the hyperuricemia patients and normouricemic controls. In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001). Therefore, TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men. Impact Journals LLC 2017-03-02 /pmc/articles/PMC5432307/ /pubmed/28460474 http://dx.doi.org/10.18632/oncotarget.15851 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Chen, Bang-Dang
Chen, Xiao-Cui
Pan, Shuo
Yang, Yi-Ning
He, Chun-Hui
Liu, Fen
Ma, Xiang
Gai, Min-Tao
Ma, Yi-Tong
TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title_full TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title_fullStr TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title_full_unstemmed TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title_short TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
title_sort tt genotype of rs2941484 in the human hnf4g gene is associated with hyperuricemia in chinese han men
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432307/
https://www.ncbi.nlm.nih.gov/pubmed/28460474
http://dx.doi.org/10.18632/oncotarget.15851
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