Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. Here, we demonstrate that the flavonoid astragalin (AG), also known as kaempferol-3-O-β-D-glucoside, induces cell death. This was prevented by the caspase inhibitors z-DEVD-FMK and z-LEHD-FM...

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Detalles Bibliográficos
Autores principales: Chen, Minghui, Cai, Fangfang, Zha, Daolong, Wang, Xueshi, Zhang, Wenjing, He, Yan, Huang, Qilai, Zhuang, Hongqin, Hua, Zi-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432309/
https://www.ncbi.nlm.nih.gov/pubmed/28199969
http://dx.doi.org/10.18632/oncotarget.15264

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