Interacting partners of FEN1 and its role in the development of anticancer therapeutics

Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1)...

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Autores principales: Kathera, Chandrasekhar, Zhang, Jing, Janardhan, Avilala, Sun, Hongfang, Ali, Wajid, Zhou, Xiaolong, He, Lingfeng, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432360/
https://www.ncbi.nlm.nih.gov/pubmed/28187440
http://dx.doi.org/10.18632/oncotarget.15176
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author Kathera, Chandrasekhar
Zhang, Jing
Janardhan, Avilala
Sun, Hongfang
Ali, Wajid
Zhou, Xiaolong
He, Lingfeng
Guo, Zhigang
author_facet Kathera, Chandrasekhar
Zhang, Jing
Janardhan, Avilala
Sun, Hongfang
Ali, Wajid
Zhou, Xiaolong
He, Lingfeng
Guo, Zhigang
author_sort Kathera, Chandrasekhar
collection PubMed
description Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.
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spelling pubmed-54323602017-05-17 Interacting partners of FEN1 and its role in the development of anticancer therapeutics Kathera, Chandrasekhar Zhang, Jing Janardhan, Avilala Sun, Hongfang Ali, Wajid Zhou, Xiaolong He, Lingfeng Guo, Zhigang Oncotarget Review Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data. Impact Journals LLC 2017-02-07 /pmc/articles/PMC5432360/ /pubmed/28187440 http://dx.doi.org/10.18632/oncotarget.15176 Text en Copyright: © 2017 Kathera et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Kathera, Chandrasekhar
Zhang, Jing
Janardhan, Avilala
Sun, Hongfang
Ali, Wajid
Zhou, Xiaolong
He, Lingfeng
Guo, Zhigang
Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title_full Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title_fullStr Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title_full_unstemmed Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title_short Interacting partners of FEN1 and its role in the development of anticancer therapeutics
title_sort interacting partners of fen1 and its role in the development of anticancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432360/
https://www.ncbi.nlm.nih.gov/pubmed/28187440
http://dx.doi.org/10.18632/oncotarget.15176
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