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A covalent antagonist for the human adenosine A(2A) receptor

The structure of the human A(2A) adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a starting point for the incorporation of reactive moieties that cause the ligand to covalently bind...

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Detalles Bibliográficos
Autores principales:	Yang, Xue, Dong, Guo, Michiels, Thomas J.M., Lenselink, Eelke B., Heitman, Laura, Louvel, Julien, IJzerman, Ad P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432479/ https://www.ncbi.nlm.nih.gov/pubmed/27915383 http://dx.doi.org/10.1007/s11302-016-9549-9

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