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Design and evaluation of EphrinA1 mutants with cerebral protective effect

The activation of EphA2 receptor by its natural ligand EphrinA1 causes blood brain barrier dysfunction, and inactivation of EphA2 reduces BBB damage in ischemic stroke. Thus, EphA2 targeted antagonists may serve as neuroprotective agents. We engineered four mutants of EphrinA1, EM1, EM2, EM3 and EM4...

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Detalles Bibliográficos
Autores principales:	Zhu, Yuanjun, Gao, Yuanqing, Zheng, Danping, Shui, Mengyang, Yu, Kuai, liu, Xiaoyan, Lin, Yuan, Su, Li, Yang, Wenxing, Wang, Yinye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432519/ https://www.ncbi.nlm.nih.gov/pubmed/28507312 http://dx.doi.org/10.1038/s41598-017-02091-7

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