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Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development

During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly ha...

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Autores principales: Tomàs, Josep, Garcia, Neus, Lanuza, Maria A., Santafé, Manel M., Tomàs, Marta, Nadal, Laura, Hurtado, Erica, Simó, Anna, Cilleros, Víctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432534/
https://www.ncbi.nlm.nih.gov/pubmed/28559796
http://dx.doi.org/10.3389/fnmol.2017.00132
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author Tomàs, Josep
Garcia, Neus
Lanuza, Maria A.
Santafé, Manel M.
Tomàs, Marta
Nadal, Laura
Hurtado, Erica
Simó, Anna
Cilleros, Víctor
author_facet Tomàs, Josep
Garcia, Neus
Lanuza, Maria A.
Santafé, Manel M.
Tomàs, Marta
Nadal, Laura
Hurtado, Erica
Simó, Anna
Cilleros, Víctor
author_sort Tomàs, Josep
collection PubMed
description During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.
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spelling pubmed-54325342017-05-30 Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development Tomàs, Josep Garcia, Neus Lanuza, Maria A. Santafé, Manel M. Tomàs, Marta Nadal, Laura Hurtado, Erica Simó, Anna Cilleros, Víctor Front Mol Neurosci Neuroscience During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination. Frontiers Media S.A. 2017-05-16 /pmc/articles/PMC5432534/ /pubmed/28559796 http://dx.doi.org/10.3389/fnmol.2017.00132 Text en Copyright © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tomàs, Josep
Garcia, Neus
Lanuza, Maria A.
Santafé, Manel M.
Tomàs, Marta
Nadal, Laura
Hurtado, Erica
Simó, Anna
Cilleros, Víctor
Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title_full Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title_fullStr Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title_full_unstemmed Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title_short Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
title_sort presynaptic membrane receptors modulate ach release, axonal competition and synapse elimination during neuromuscular junction development
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432534/
https://www.ncbi.nlm.nih.gov/pubmed/28559796
http://dx.doi.org/10.3389/fnmol.2017.00132
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