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Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development
During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly ha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432534/ https://www.ncbi.nlm.nih.gov/pubmed/28559796 http://dx.doi.org/10.3389/fnmol.2017.00132 |
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author | Tomàs, Josep Garcia, Neus Lanuza, Maria A. Santafé, Manel M. Tomàs, Marta Nadal, Laura Hurtado, Erica Simó, Anna Cilleros, Víctor |
author_facet | Tomàs, Josep Garcia, Neus Lanuza, Maria A. Santafé, Manel M. Tomàs, Marta Nadal, Laura Hurtado, Erica Simó, Anna Cilleros, Víctor |
author_sort | Tomàs, Josep |
collection | PubMed |
description | During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination. |
format | Online Article Text |
id | pubmed-5432534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54325342017-05-30 Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development Tomàs, Josep Garcia, Neus Lanuza, Maria A. Santafé, Manel M. Tomàs, Marta Nadal, Laura Hurtado, Erica Simó, Anna Cilleros, Víctor Front Mol Neurosci Neuroscience During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination. Frontiers Media S.A. 2017-05-16 /pmc/articles/PMC5432534/ /pubmed/28559796 http://dx.doi.org/10.3389/fnmol.2017.00132 Text en Copyright © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tomàs, Josep Garcia, Neus Lanuza, Maria A. Santafé, Manel M. Tomàs, Marta Nadal, Laura Hurtado, Erica Simó, Anna Cilleros, Víctor Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title | Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title_full | Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title_fullStr | Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title_full_unstemmed | Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title_short | Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development |
title_sort | presynaptic membrane receptors modulate ach release, axonal competition and synapse elimination during neuromuscular junction development |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432534/ https://www.ncbi.nlm.nih.gov/pubmed/28559796 http://dx.doi.org/10.3389/fnmol.2017.00132 |
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