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Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence,...

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Autores principales: Yang, Jie, Li, Wenjuan, Ng, Tzi Bun, Deng, Xiangzhen, Lin, Juan, Ye, Xiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432550/
https://www.ncbi.nlm.nih.gov/pubmed/28559880
http://dx.doi.org/10.3389/fmicb.2017.00832
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author Yang, Jie
Li, Wenjuan
Ng, Tzi Bun
Deng, Xiangzhen
Lin, Juan
Ye, Xiuyun
author_facet Yang, Jie
Li, Wenjuan
Ng, Tzi Bun
Deng, Xiangzhen
Lin, Juan
Ye, Xiuyun
author_sort Yang, Jie
collection PubMed
description Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical properties, and expression to immobilization and applications. This review is not intended to be all-encompassing; instead, we highlighted some of the latest developments in basic and applied laccase research with an emphasis on laccase-mediated bioremediation of pharmaceuticals, especially antibiotics. Pharmaceuticals are a broad class of emerging organic contaminants that are recalcitrant and prevalent. The recent surge in the relevant literature justifies a short review on the topic. Since low laccase yields in natural and genetically modified hosts constitute a bottleneck to industrial-scale applications, we also accentuated a genus of laccase-producing white-rot fungi, Cerrena, and included a discussion with regards to regulation of laccase expression.
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spelling pubmed-54325502017-05-30 Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation Yang, Jie Li, Wenjuan Ng, Tzi Bun Deng, Xiangzhen Lin, Juan Ye, Xiuyun Front Microbiol Microbiology Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical properties, and expression to immobilization and applications. This review is not intended to be all-encompassing; instead, we highlighted some of the latest developments in basic and applied laccase research with an emphasis on laccase-mediated bioremediation of pharmaceuticals, especially antibiotics. Pharmaceuticals are a broad class of emerging organic contaminants that are recalcitrant and prevalent. The recent surge in the relevant literature justifies a short review on the topic. Since low laccase yields in natural and genetically modified hosts constitute a bottleneck to industrial-scale applications, we also accentuated a genus of laccase-producing white-rot fungi, Cerrena, and included a discussion with regards to regulation of laccase expression. Frontiers Media S.A. 2017-05-16 /pmc/articles/PMC5432550/ /pubmed/28559880 http://dx.doi.org/10.3389/fmicb.2017.00832 Text en Copyright © 2017 Yang, Li, Ng, Deng, Lin and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Yang, Jie
Li, Wenjuan
Ng, Tzi Bun
Deng, Xiangzhen
Lin, Juan
Ye, Xiuyun
Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title_full Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title_fullStr Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title_full_unstemmed Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title_short Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation
title_sort laccases: production, expression regulation, and applications in pharmaceutical biodegradation
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432550/
https://www.ncbi.nlm.nih.gov/pubmed/28559880
http://dx.doi.org/10.3389/fmicb.2017.00832
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