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Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432579/ https://www.ncbi.nlm.nih.gov/pubmed/28559797 http://dx.doi.org/10.3389/fncel.2017.00140 |
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author | Fasano, Caroline Rocchetti, Jill Pietrajtis, Katarzyna Zander, Johannes-Friedrich Manseau, Frédéric Sakae, Diana Y. Marcus-Sells, Maya Ramet, Lauriane Morel, Lydie J. Carrel, Damien Dumas, Sylvie Bolte, Susanne Bernard, Véronique Vigneault, Erika Goutagny, Romain Ahnert-Hilger, Gudrun Giros, Bruno Daumas, Stéphanie Williams, Sylvain El Mestikawy, Salah |
author_facet | Fasano, Caroline Rocchetti, Jill Pietrajtis, Katarzyna Zander, Johannes-Friedrich Manseau, Frédéric Sakae, Diana Y. Marcus-Sells, Maya Ramet, Lauriane Morel, Lydie J. Carrel, Damien Dumas, Sylvie Bolte, Susanne Bernard, Véronique Vigneault, Erika Goutagny, Romain Ahnert-Hilger, Gudrun Giros, Bruno Daumas, Stéphanie Williams, Sylvain El Mestikawy, Salah |
author_sort | Fasano, Caroline |
collection | PubMed |
description | Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer’s collaterals – CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network. |
format | Online Article Text |
id | pubmed-5432579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54325792017-05-30 Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells Fasano, Caroline Rocchetti, Jill Pietrajtis, Katarzyna Zander, Johannes-Friedrich Manseau, Frédéric Sakae, Diana Y. Marcus-Sells, Maya Ramet, Lauriane Morel, Lydie J. Carrel, Damien Dumas, Sylvie Bolte, Susanne Bernard, Véronique Vigneault, Erika Goutagny, Romain Ahnert-Hilger, Gudrun Giros, Bruno Daumas, Stéphanie Williams, Sylvain El Mestikawy, Salah Front Cell Neurosci Neuroscience Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer’s collaterals – CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network. Frontiers Media S.A. 2017-05-16 /pmc/articles/PMC5432579/ /pubmed/28559797 http://dx.doi.org/10.3389/fncel.2017.00140 Text en Copyright © 2017 Fasano, Rocchetti, Pietrajtis, Zander, Manseau, Sakae, Marcus-Sells, Ramet, Morel, Carrel, Dumas, Bolte, Bernard, Vigneault, Goutagny, Ahnert-Hilger, Giros, Daumas, Williams and El Mestikawy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Fasano, Caroline Rocchetti, Jill Pietrajtis, Katarzyna Zander, Johannes-Friedrich Manseau, Frédéric Sakae, Diana Y. Marcus-Sells, Maya Ramet, Lauriane Morel, Lydie J. Carrel, Damien Dumas, Sylvie Bolte, Susanne Bernard, Véronique Vigneault, Erika Goutagny, Romain Ahnert-Hilger, Gudrun Giros, Bruno Daumas, Stéphanie Williams, Sylvain El Mestikawy, Salah Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title_full | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title_fullStr | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title_full_unstemmed | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title_short | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells |
title_sort | regulation of the hippocampal network by vglut3-positive cck- gabaergic basket cells |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432579/ https://www.ncbi.nlm.nih.gov/pubmed/28559797 http://dx.doi.org/10.3389/fncel.2017.00140 |
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