Cargando…
Serum Uric Acid level in the severity of Congestive Heart Failure (CHF)
BACKGROUND AND OBJECTIVE: It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure. METHODS: We analyze 285 patients...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432699/ https://www.ncbi.nlm.nih.gov/pubmed/28523032 http://dx.doi.org/10.12669/pjms.332.11779 |
_version_ | 1783236689443946496 |
---|---|
author | khan, Adnan Shah, Mohammad Hassan khan, Sarbiland Shamim, Umama Arshad, Sanan |
author_facet | khan, Adnan Shah, Mohammad Hassan khan, Sarbiland Shamim, Umama Arshad, Sanan |
author_sort | khan, Adnan |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure. METHODS: We analyze 285 patients with a diagnosis of Congestive heart failure admitted in Lady Reading Hospital Peshawar from March 1(st) to August 2016. Age group of patients was 17- 67 years. New York Health Association (NYHA) scoring were used to access the severity of Congestive Heart Failure. Serum UA level >7.0 mg/dl was considered high. RESULTS: Total 285 patients with CHF were analyzed with a mean age of 54±2.8 years in which males were 65.96% and 34.03% were female. 40% were in class II of New York Health Association (NYHA), 32.63% in class III and 25.61% in class IV and 1.75% were in class I. Out of 285, 59.29% met the definition of hyperuricemia. In which 83.43% were male and 16.57% were female. Most of the Hyperuricemic patients 62.13% were in age group of 51- 60 years, with a mean age of 57±4.5 years. We found a significant correlation between uric acid level and BNP (p= <0.001), and use of diuretics (p=<0.001). 34.93% of the Hyperuricemic CHF patients were in NYHA III and NYHA IV whose SUA was above 8 mg/dl as compared to 31.57% Hyperuricemic CHF patients whose SUA was below 8 mg/dl. CONCLUSION: High serum Uric acid was observed in 59.29% of patients with CHF. The observed significant correlation between UA level and some established prognostic markers in these patients may indicate that serum UA could provide additional prognostic information in this population. SUA as a marker can be measured anywhere at a low cost to help identify high-risk patients with CHF. Lowing uric acid is expected to be a new approach for prevention and therapy of HF. |
format | Online Article Text |
id | pubmed-5432699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54326992017-05-18 Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) khan, Adnan Shah, Mohammad Hassan khan, Sarbiland Shamim, Umama Arshad, Sanan Pak J Med Sci Original Article BACKGROUND AND OBJECTIVE: It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure. METHODS: We analyze 285 patients with a diagnosis of Congestive heart failure admitted in Lady Reading Hospital Peshawar from March 1(st) to August 2016. Age group of patients was 17- 67 years. New York Health Association (NYHA) scoring were used to access the severity of Congestive Heart Failure. Serum UA level >7.0 mg/dl was considered high. RESULTS: Total 285 patients with CHF were analyzed with a mean age of 54±2.8 years in which males were 65.96% and 34.03% were female. 40% were in class II of New York Health Association (NYHA), 32.63% in class III and 25.61% in class IV and 1.75% were in class I. Out of 285, 59.29% met the definition of hyperuricemia. In which 83.43% were male and 16.57% were female. Most of the Hyperuricemic patients 62.13% were in age group of 51- 60 years, with a mean age of 57±4.5 years. We found a significant correlation between uric acid level and BNP (p= <0.001), and use of diuretics (p=<0.001). 34.93% of the Hyperuricemic CHF patients were in NYHA III and NYHA IV whose SUA was above 8 mg/dl as compared to 31.57% Hyperuricemic CHF patients whose SUA was below 8 mg/dl. CONCLUSION: High serum Uric acid was observed in 59.29% of patients with CHF. The observed significant correlation between UA level and some established prognostic markers in these patients may indicate that serum UA could provide additional prognostic information in this population. SUA as a marker can be measured anywhere at a low cost to help identify high-risk patients with CHF. Lowing uric acid is expected to be a new approach for prevention and therapy of HF. Professional Medical Publications 2017 /pmc/articles/PMC5432699/ /pubmed/28523032 http://dx.doi.org/10.12669/pjms.332.11779 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article khan, Adnan Shah, Mohammad Hassan khan, Sarbiland Shamim, Umama Arshad, Sanan Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title | Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title_full | Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title_fullStr | Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title_full_unstemmed | Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title_short | Serum Uric Acid level in the severity of Congestive Heart Failure (CHF) |
title_sort | serum uric acid level in the severity of congestive heart failure (chf) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432699/ https://www.ncbi.nlm.nih.gov/pubmed/28523032 http://dx.doi.org/10.12669/pjms.332.11779 |
work_keys_str_mv | AT khanadnan serumuricacidlevelintheseverityofcongestiveheartfailurechf AT shahmohammadhassan serumuricacidlevelintheseverityofcongestiveheartfailurechf AT khansarbiland serumuricacidlevelintheseverityofcongestiveheartfailurechf AT shamimumama serumuricacidlevelintheseverityofcongestiveheartfailurechf AT arshadsanan serumuricacidlevelintheseverityofcongestiveheartfailurechf |