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Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison
OBJECTIVE: To describe bacteriological profile, morbidity and mortality of acute bacterial meningitis (ABM) in children and to compare these parameters before and after the introduction of Pneumococcal vaccine in Pakistan National Immunization Program. METHODS: The present descriptive study was cond...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432721/ https://www.ncbi.nlm.nih.gov/pubmed/28523054 http://dx.doi.org/10.12669/pjms.332.11891 |
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author | Bari, Attia Zeeshan, Fatima Zafar, Aizza Ejaz, Hasan Jabeen, Uzma Rathore, Ahsan Waheed |
author_facet | Bari, Attia Zeeshan, Fatima Zafar, Aizza Ejaz, Hasan Jabeen, Uzma Rathore, Ahsan Waheed |
author_sort | Bari, Attia |
collection | PubMed |
description | OBJECTIVE: To describe bacteriological profile, morbidity and mortality of acute bacterial meningitis (ABM) in children and to compare these parameters before and after the introduction of Pneumococcal vaccine in Pakistan National Immunization Program. METHODS: The present descriptive study was conducted at the Department of Paediatric Medicine of The Children’s Hospital Lahore from January 2012 to December 2015. A total of 503 children one month to five years of age admitted with diagnosis of meningitis were included. Complete blood count, CSF cytology, biochemistry, culture sensitivity and blood culture sensitivity were performed. RESULTS: Frequency of meningitis decreased by 50% in 2013-2015 (199 [2012] vs 304 [2013-2015). Most children in both groups were under one year of age. More neurological complications were seen in the group 2, 20% vs 17%. CSF culture positivity decreased from 12% to 6.6%. Streptococcus pneumoniae isolation decreased from 5 (2.5%) in 2012 to 4 (1.3%) in 2013-2015. Refusal to take feed (p=0.002), impaired sensorium (p=<0.001), severe malnutrition (p=0.001), prolonged duration of symptoms (p=<0.001) and incomplete vaccination status (0.005) were associated with mortality. Mortality rate decreased from 20 (10%) in 2012 to 17 (5.6%) in 2013-2015 but more children developed neurological sequelae 2.7% versus 1%. CONCLUSION: Acute bacterial meningitis mostly affected children <1 year. Frequency of Streptococcus pneumoniae and mortality of meningitis decreased significantly after PCV but more neurological complications developed in those children who were unvaccinated in 2013-2015 compared to 2012. |
format | Online Article Text |
id | pubmed-5432721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54327212017-05-18 Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison Bari, Attia Zeeshan, Fatima Zafar, Aizza Ejaz, Hasan Jabeen, Uzma Rathore, Ahsan Waheed Pak J Med Sci Original Article OBJECTIVE: To describe bacteriological profile, morbidity and mortality of acute bacterial meningitis (ABM) in children and to compare these parameters before and after the introduction of Pneumococcal vaccine in Pakistan National Immunization Program. METHODS: The present descriptive study was conducted at the Department of Paediatric Medicine of The Children’s Hospital Lahore from January 2012 to December 2015. A total of 503 children one month to five years of age admitted with diagnosis of meningitis were included. Complete blood count, CSF cytology, biochemistry, culture sensitivity and blood culture sensitivity were performed. RESULTS: Frequency of meningitis decreased by 50% in 2013-2015 (199 [2012] vs 304 [2013-2015). Most children in both groups were under one year of age. More neurological complications were seen in the group 2, 20% vs 17%. CSF culture positivity decreased from 12% to 6.6%. Streptococcus pneumoniae isolation decreased from 5 (2.5%) in 2012 to 4 (1.3%) in 2013-2015. Refusal to take feed (p=0.002), impaired sensorium (p=<0.001), severe malnutrition (p=0.001), prolonged duration of symptoms (p=<0.001) and incomplete vaccination status (0.005) were associated with mortality. Mortality rate decreased from 20 (10%) in 2012 to 17 (5.6%) in 2013-2015 but more children developed neurological sequelae 2.7% versus 1%. CONCLUSION: Acute bacterial meningitis mostly affected children <1 year. Frequency of Streptococcus pneumoniae and mortality of meningitis decreased significantly after PCV but more neurological complications developed in those children who were unvaccinated in 2013-2015 compared to 2012. Professional Medical Publications 2017 /pmc/articles/PMC5432721/ /pubmed/28523054 http://dx.doi.org/10.12669/pjms.332.11891 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bari, Attia Zeeshan, Fatima Zafar, Aizza Ejaz, Hasan Jabeen, Uzma Rathore, Ahsan Waheed Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title | Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title_full | Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title_fullStr | Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title_full_unstemmed | Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title_short | Acute bacterial meningitis in children presenting to The Children’s Hospital Lahore before and after pneumococcal vaccine in Pakistan National Immunization Program; A comparison |
title_sort | acute bacterial meningitis in children presenting to the children’s hospital lahore before and after pneumococcal vaccine in pakistan national immunization program; a comparison |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432721/ https://www.ncbi.nlm.nih.gov/pubmed/28523054 http://dx.doi.org/10.12669/pjms.332.11891 |
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