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Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study

BACKGROUND: To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD). METHODS: Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained...

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Autores principales: Kaneta, Tomohiro, Katsuse, Omi, Hirano, Takamasa, Ogawa, Matsuyoshi, Shihikura-Hino, Ayako, Yoshida, Keisuke, Odawara, Toshinari, Hirayasu, Yoshio, Inoue, Tomio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433075/
https://www.ncbi.nlm.nih.gov/pubmed/28506213
http://dx.doi.org/10.1186/s12883-017-0870-x
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author Kaneta, Tomohiro
Katsuse, Omi
Hirano, Takamasa
Ogawa, Matsuyoshi
Shihikura-Hino, Ayako
Yoshida, Keisuke
Odawara, Toshinari
Hirayasu, Yoshio
Inoue, Tomio
author_facet Kaneta, Tomohiro
Katsuse, Omi
Hirano, Takamasa
Ogawa, Matsuyoshi
Shihikura-Hino, Ayako
Yoshida, Keisuke
Odawara, Toshinari
Hirayasu, Yoshio
Inoue, Tomio
author_sort Kaneta, Tomohiro
collection PubMed
description BACKGROUND: To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD). METHODS: Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD(1.5) and PLD(2.5), respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28). Voxel-based analyses were performed for ASL-MRI and SPECT using Mini-Mental State Examination (MMSE) scores as covariates. Differences in CBF between PLD(1.5) and PLD(2.5) were assessed using a paired t-test with SPM12. RESULTS: Significant positive correlations were observed between MMSE scores and CBF at PLD(1.5) in the right posterior cingulate cortex (PCC), and both temporo-parietal association cortexes. At PLD(2.5), significant positive correlations were determined for MMSE scores and CBF in the superior parietal lobule and the right temporo-parietal association cortex. SPECT showed significant positive correlations in the PCC and both temporo-parietal association cortexes (right-side dominant). PLD(1.5) showed significantly higher CBF than PLD(2.5) in the proximal areas of vascular territories of the anterior, middle, and posterior cerebral arteries. CONCLUSIONS: Significant positive correlations in CBF, measured with both ASL-MRI and SPECT, with cognition were found in the PCC and temporo-parietal association cortexes. PLD(1.5) and PLD(2.5) showed similar correlations with cognition, although the CBF images had significant differences.
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spelling pubmed-54330752017-05-17 Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study Kaneta, Tomohiro Katsuse, Omi Hirano, Takamasa Ogawa, Matsuyoshi Shihikura-Hino, Ayako Yoshida, Keisuke Odawara, Toshinari Hirayasu, Yoshio Inoue, Tomio BMC Neurol Research Article BACKGROUND: To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer’s disease (AD). METHODS: Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD(1.5) and PLD(2.5), respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28). Voxel-based analyses were performed for ASL-MRI and SPECT using Mini-Mental State Examination (MMSE) scores as covariates. Differences in CBF between PLD(1.5) and PLD(2.5) were assessed using a paired t-test with SPM12. RESULTS: Significant positive correlations were observed between MMSE scores and CBF at PLD(1.5) in the right posterior cingulate cortex (PCC), and both temporo-parietal association cortexes. At PLD(2.5), significant positive correlations were determined for MMSE scores and CBF in the superior parietal lobule and the right temporo-parietal association cortex. SPECT showed significant positive correlations in the PCC and both temporo-parietal association cortexes (right-side dominant). PLD(1.5) showed significantly higher CBF than PLD(2.5) in the proximal areas of vascular territories of the anterior, middle, and posterior cerebral arteries. CONCLUSIONS: Significant positive correlations in CBF, measured with both ASL-MRI and SPECT, with cognition were found in the PCC and temporo-parietal association cortexes. PLD(1.5) and PLD(2.5) showed similar correlations with cognition, although the CBF images had significant differences. BioMed Central 2017-05-15 /pmc/articles/PMC5433075/ /pubmed/28506213 http://dx.doi.org/10.1186/s12883-017-0870-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kaneta, Tomohiro
Katsuse, Omi
Hirano, Takamasa
Ogawa, Matsuyoshi
Shihikura-Hino, Ayako
Yoshida, Keisuke
Odawara, Toshinari
Hirayasu, Yoshio
Inoue, Tomio
Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title_full Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title_fullStr Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title_full_unstemmed Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title_short Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer’s disease: a cross-sectional study
title_sort voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion mri in patients with alzheimer’s disease: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433075/
https://www.ncbi.nlm.nih.gov/pubmed/28506213
http://dx.doi.org/10.1186/s12883-017-0870-x
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