Cargando…

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

The hepatitis C virus (HCV) glycoprotein E2 is the major target of neutralizing antibodies and is therefore highly relevant for vaccine design. Its structure features a central immunoglobulin (Ig)-like β-sandwich that contributes to the binding site for the cellular receptor CD81. We show that a syn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasiliauskaite, Ieva, Owsianka, Ania, England, Patrick, Khan, Abdul Ghafoor, Cole, Sarah, Bankwitz, Dorothea, Foung, Steven K. H., Pietschmann, Thomas, Marcotrigiano, Joseph, Rey, Felix A., Patel, Arvind H., Krey, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433095/ https://www.ncbi.nlm.nih.gov/pubmed/28512091 http://dx.doi.org/10.1128/mBio.00382-17

Ejemplares similares

Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen
por: Bankwitz, Dorothea, et al.
Publicado: (2022)

Comprehensive linker-scanning mutagenesis of the hepatitis C virus E1 and E2 envelope glycoproteins reveals new structure–function relationships
por: Rychłowska, Małgorzata, et al.
Publicado: (2011)

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2
por: Ströh, Luisa J., et al.
Publicado: (2018)

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
por: Owsianka, Ania M., et al.
Publicado: (2008)

CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
por: Witteveldt, Jeroen, et al.
Publicado: (2009)

Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication
por: Chhatwal, Patrick, et al.
Publicado: (2012)

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate
por: Keck, Zhen-yong, et al.
Publicado: (2012)

Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus
por: Naik, Amruta S., et al.
Publicado: (2017)

Conformation of membrane-inserted P-glycoprotein
por: Stockner, Thomas, et al.
Publicado: (2010)

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape
por: Krey, Thomas, et al.
Publicado: (2013)

Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies
por: Bankwitz, Dorothea, et al.
Publicado: (2021)

MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles
por: Menzel, Nicolas, et al.
Publicado: (2012)

HCV Glycoprotein Structure and Implications for B-Cell Vaccine Development
por: Ströh, Luisa J., et al.
Publicado: (2020)

Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Entry Factors
por: Bitzegeio, Julia, et al.
Publicado: (2010)

Structure of the Core Ectodomain of the Hepatitis C Virus Envelope Glycoprotein 2
por: Khan, Abdul Ghafoor, et al.
Publicado: (2014)

The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule
por: Krey, Thomas, et al.
Publicado: (2010)

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies
por: Ratnapriya, Sneha, et al.
Publicado: (2023)

Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and Disorder
por: Yost, Samantha A., et al.
Publicado: (2018)

Incorporation of Hepatitis C Virus E1 and E2 Glycoproteins: The Keystones on a Peculiar Virion
por: Vieyres, Gabrielle, et al.
Publicado: (2014)

The Conformational Flexibility of an Internal Fusion Peptide from Sars-Cov Spike Glycoprotein is Modulated by Lipid Membrane Composition
por: Basso, Luis G.M., et al.
Publicado: (2014)

The HIV Env Glycoprotein Conformational States on Cells and Viruses
por: Zhao, Connie, et al.
Publicado: (2022)

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
por: Henderson, Rory, et al.
Publicado: (2019)

An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development
por: Salas, Jordan H., et al.
Publicado: (2022)

The Hepatitis C Virus E1 Glycoprotein Undergoes Productive Folding but Accelerated Degradation When Expressed as an Individual Subunit in CHO Cells
por: Botti, Valentina, et al.
Publicado: (2011)

Hepatitis C Virus Hypervariable Region 1 Variants Presented on Hepatitis B Virus Capsid-Like Particles Induce Cross-Neutralizing Antibodies
por: Lange, Milena, et al.
Publicado: (2014)

Conformational Requirements for Glycoprotein Reglucosylation in the Endoplasmic Reticulum
por: Trombetta, E. Sergio, et al.
Publicado: (2000)

Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles
por: Czarnota, Anna, et al.
Publicado: (2023)

Non-random Escape Pathways from a Broadly Neutralizing Human Monoclonal Antibody Map to a Highly Conserved Region on the Hepatitis C Virus E2 Glycoprotein Encompassing Amino Acids 412–423
por: Keck, Zhen-yong, et al.
Publicado: (2014)

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling
por: Durbin, Ann Fiegen, et al.
Publicado: (2016)

Which conformation does the ABC transporter P-glycoprotein adopt in the physiological membrane environment?
por: Stockner, Thomas, et al.
Publicado: (2012)

Conformability of flexible sheets on spherical surfaces
por: Liu, Siyi, et al.
Publicado: (2023)

Influence of Mg(2+) on the conformational flexibility of a tetracycline aptamer
por: Hetzke, Thilo, et al.
Publicado: (2019)

An Overview of the Importance of Conformational Flexibility in Gene Regulation by the Transcription Factors
por: Khan, Shagufta H., et al.
Publicado: (2009)

Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein
por: Al Olaby, Reem R., et al.
Publicado: (2014)

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells
por: Banse, Pia, et al.
Publicado: (2018)

An ensemble of flexible conformations underlies mechanotransduction by the cadherin–catenin adhesion complex
por: Bush, Martin, et al.
Publicado: (2019)

Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages
por: Eisfeld, Hannah S., et al.
Publicado: (2021)

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
por: Amaral, M., et al.
Publicado: (2017)

Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein()
por: Duquerroy, Stéphane, et al.
Publicado: (2005)

Human immunoglobulin E flexes between acutely bent and extended conformations
por: Drinkwater, Nyssa, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3ug74aqnu1tl6hhjl9dvp5e0re