A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characteri...

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Detalles Bibliográficos
Autores principales: Shao, Taofeng, Gong, Zhiming, Su, Tianyi, Hao, Wei, Che, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433183/
https://www.ncbi.nlm.nih.gov/pubmed/28546839
http://dx.doi.org/10.3762/bjoc.13.82
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author Shao, Taofeng
Gong, Zhiming
Su, Tianyi
Hao, Wei
Che, Chao
author_facet Shao, Taofeng
Gong, Zhiming
Su, Tianyi
Hao, Wei
Che, Chao
author_sort Shao, Taofeng
collection PubMed
description Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields.
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spelling pubmed-54331832017-05-25 A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy Shao, Taofeng Gong, Zhiming Su, Tianyi Hao, Wei Che, Chao Beilstein J Org Chem Full Research Paper Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields. Beilstein-Institut 2017-05-04 /pmc/articles/PMC5433183/ /pubmed/28546839 http://dx.doi.org/10.3762/bjoc.13.82 Text en Copyright © 2017, Shao et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Shao, Taofeng
Gong, Zhiming
Su, Tianyi
Hao, Wei
Che, Chao
A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_full A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_fullStr A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_full_unstemmed A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_short A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy
title_sort practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-gbb transformation strategy
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433183/
https://www.ncbi.nlm.nih.gov/pubmed/28546839
http://dx.doi.org/10.3762/bjoc.13.82
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