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Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin

BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. OBJECTIVE: We propose that MOG has a central role...

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Detalles Bibliográficos
Autores principales: ’t Hart, Bert A, Weissert, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433322/
https://www.ncbi.nlm.nih.gov/pubmed/28607715
http://dx.doi.org/10.1177/2055217316630999
Descripción
Sumario:BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. OBJECTIVE: We propose that MOG has a central role in the regulation of tolerance and autoimmunity. CONCLUSION: The interaction of MOG with DC-SIGN, an innate antigen receptor of myeloid antigen-presenting cells (m-APCs), present inside the CNS (microglia) or in draining lymph nodes (dendritic cells; DCs), keeps these cells in an immature/tolerogenic state. We postulate that this tolerogenic mechanism may be disturbed in MS by unknown factors.