Cargando…

Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression

A promising new avenue of MS research that may lead to a better understanding of pathogenesis, progression and therapeutic response, and to development of new therapies, comes from the recent identification of defined immune cell populations that are highly heritable. Such stable populations have be...

Descripción completa

Detalles Bibliográficos
Autores principales: Booth, David R, Fewings, Nicole L, Parnell, Grant P, McKay, Fiona C, Stewart, Graeme J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433329/
https://www.ncbi.nlm.nih.gov/pubmed/28607721
http://dx.doi.org/10.1177/2055217316637087
_version_ 1783236831133827072
author Booth, David R
Fewings, Nicole L
Parnell, Grant P
McKay, Fiona C
Stewart, Graeme J
author_facet Booth, David R
Fewings, Nicole L
Parnell, Grant P
McKay, Fiona C
Stewart, Graeme J
author_sort Booth, David R
collection PubMed
description A promising new avenue of MS research that may lead to a better understanding of pathogenesis, progression and therapeutic response, and to development of new therapies, comes from the recent identification of defined immune cell populations that are highly heritable. Such stable populations have been identified in three recent papers using extensive flow cytometric panels to investigate twin and family cohorts. They showed that while most of the variation in immune cell populations between individuals was not heritable, some was. This heritability was sometimes very high, and the authors concluded that it likely contributes to variability in response among individuals for disease and drug response traits.
format Online
Article
Text
id pubmed-5433329
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-54333292017-06-12 Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression Booth, David R Fewings, Nicole L Parnell, Grant P McKay, Fiona C Stewart, Graeme J Mult Scler J Exp Transl Clin Commentary A promising new avenue of MS research that may lead to a better understanding of pathogenesis, progression and therapeutic response, and to development of new therapies, comes from the recent identification of defined immune cell populations that are highly heritable. Such stable populations have been identified in three recent papers using extensive flow cytometric panels to investigate twin and family cohorts. They showed that while most of the variation in immune cell populations between individuals was not heritable, some was. This heritability was sometimes very high, and the authors concluded that it likely contributes to variability in response among individuals for disease and drug response traits. SAGE Publications 2016-03-11 /pmc/articles/PMC5433329/ /pubmed/28607721 http://dx.doi.org/10.1177/2055217316637087 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Booth, David R
Fewings, Nicole L
Parnell, Grant P
McKay, Fiona C
Stewart, Graeme J
Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title_full Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title_fullStr Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title_full_unstemmed Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title_short Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression
title_sort differences in common heritable blood immune cell populations may underlie ms susceptibility and progression
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433329/
https://www.ncbi.nlm.nih.gov/pubmed/28607721
http://dx.doi.org/10.1177/2055217316637087
work_keys_str_mv AT boothdavidr differencesincommonheritablebloodimmunecellpopulationsmayunderliemssusceptibilityandprogression
AT fewingsnicolel differencesincommonheritablebloodimmunecellpopulationsmayunderliemssusceptibilityandprogression
AT parnellgrantp differencesincommonheritablebloodimmunecellpopulationsmayunderliemssusceptibilityandprogression
AT mckayfionac differencesincommonheritablebloodimmunecellpopulationsmayunderliemssusceptibilityandprogression
AT stewartgraemej differencesincommonheritablebloodimmunecellpopulationsmayunderliemssusceptibilityandprogression