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Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

BACKGROUND: Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron an...

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Detalles Bibliográficos
Autores principales:	Gresle, Melissa M, Liu, Yaou, Kilpatrick, Trevor J, Kemper, Dennis, Wu, Qi-Zhu, Hu, Bing, Fu, Qing-Ling, So, Kwok-Fai, Sheng, Guoqing, Huang, Guanrong, Pepinsky, Blake, Butzkueven, Helmut, Mi, Sha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433342/ https://www.ncbi.nlm.nih.gov/pubmed/28607723 http://dx.doi.org/10.1177/2055217316641704

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