Cargando…
Safety, tolerability and pharmacodynamics of a novel immunomodulator, MIS416, in patients with chronic progressive multiple sclerosis
BACKGROUND: Preclinical studies have demonstrated that MIS416, a bacterially derived immune modulator, targets myeloid cells following systemic delivery. MIS416 stimulated myeloid cells have the capacity to regulate innate inflammation, a potential therapeutic target for progressive multiple scleros...
Autores principales: | Luckey, Alison M, Anderson, Tim, Silverman, Michael H, Webster, Gill |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433401/ https://www.ncbi.nlm.nih.gov/pubmed/28607691 http://dx.doi.org/10.1177/2055217315583385 |
Ejemplares similares
-
Evaluation of neurological changes in secondary progressive multiple sclerosis patients treated with immune modulator MIS416: results from a feasibility study
por: Webster, Gill A., et al.
Publicado: (2017) -
Targeting Innate Receptors with MIS416 Reshapes Th Responses and Suppresses CNS Disease in a Mouse Model of Multiple Sclerosis
por: White, Madeleine, et al.
Publicado: (2014) -
MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells
por: Mainini, Francesco, et al.
Publicado: (2018) -
Bridging Small Molecules to Modified Bacterial Microparticles Using a Disulphide Linkage: MIS416 as a Cargo Delivery System
por: Mainini, Francesco, et al.
Publicado: (2015) -
MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu
por: Lee, Byung-Chul, et al.
Publicado: (2018)