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Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis
BACKGROUND: Multiple sclerosis (MS) initiates with a first attack or clinically isolated syndrome (CIS). The importance of an early treatment in MS leads to the search, as soon as possible, for novel biomarkers which can predict conversion from CIS to MS. OBJECTIVE: The purpose of this study was to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433434/ https://www.ncbi.nlm.nih.gov/pubmed/28607709 http://dx.doi.org/10.1177/2055217315620935 |
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author | Menéndez-Valladares, P García-Sánchez, MI Cuadri Benítez, P Lucas, M Adorna Martínez, M Carranco Galán, V García De Veas Silva, JL Bermudo Guitarte, C Izquierdo Ayuso, G |
author_facet | Menéndez-Valladares, P García-Sánchez, MI Cuadri Benítez, P Lucas, M Adorna Martínez, M Carranco Galán, V García De Veas Silva, JL Bermudo Guitarte, C Izquierdo Ayuso, G |
author_sort | Menéndez-Valladares, P |
collection | PubMed |
description | BACKGROUND: Multiple sclerosis (MS) initiates with a first attack or clinically isolated syndrome (CIS). The importance of an early treatment in MS leads to the search, as soon as possible, for novel biomarkers which can predict conversion from CIS to MS. OBJECTIVE: The purpose of this study was to assess the predictive value of the kappa index ([Formula: see text] index), using kappa free light light chains ([Formula: see text] FLCs) in cerebrospinal fluid (CSF), for the conversion of CIS patients to MS, and compare its accuracy with other parameters used in clinical practice. METHODS: FLC levels were analysed in CSF from 176 patients: 70 as control group, 77 CIS, and 29 relapsing–remitting MS. FLC levels were quantified by nephelometry. RESULTS: [Formula: see text] Index sensitivity and specificity (93.1%; 95.7%) was higher than those from the immunoglobulin G (IgG) index (75.9%; 94.3%), and lower than those from oligoclonal IgG bands (OCGBs) (96.5%; 98.6%). The optimal cut-off for [Formula: see text] index was 10.62. Most of the CIS patients with [Formula: see text] index >10.62 presented OCGBs, IgG index >0.56 and fulfilled magnetic resonance imaging (MRI) criteria. CONCLUSION: CIS patients above [Formula: see text] index cut-off of 10.62 present 7.34-fold risk of conversion to MS than CIS below this value. The [Formula: see text] index correlated with positive OCGBs, IgG index above 0.56 and MRI criteria. |
format | Online Article Text |
id | pubmed-5433434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54334342017-06-12 Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis Menéndez-Valladares, P García-Sánchez, MI Cuadri Benítez, P Lucas, M Adorna Martínez, M Carranco Galán, V García De Veas Silva, JL Bermudo Guitarte, C Izquierdo Ayuso, G Mult Scler J Exp Transl Clin Original Article BACKGROUND: Multiple sclerosis (MS) initiates with a first attack or clinically isolated syndrome (CIS). The importance of an early treatment in MS leads to the search, as soon as possible, for novel biomarkers which can predict conversion from CIS to MS. OBJECTIVE: The purpose of this study was to assess the predictive value of the kappa index ([Formula: see text] index), using kappa free light light chains ([Formula: see text] FLCs) in cerebrospinal fluid (CSF), for the conversion of CIS patients to MS, and compare its accuracy with other parameters used in clinical practice. METHODS: FLC levels were analysed in CSF from 176 patients: 70 as control group, 77 CIS, and 29 relapsing–remitting MS. FLC levels were quantified by nephelometry. RESULTS: [Formula: see text] Index sensitivity and specificity (93.1%; 95.7%) was higher than those from the immunoglobulin G (IgG) index (75.9%; 94.3%), and lower than those from oligoclonal IgG bands (OCGBs) (96.5%; 98.6%). The optimal cut-off for [Formula: see text] index was 10.62. Most of the CIS patients with [Formula: see text] index >10.62 presented OCGBs, IgG index >0.56 and fulfilled magnetic resonance imaging (MRI) criteria. CONCLUSION: CIS patients above [Formula: see text] index cut-off of 10.62 present 7.34-fold risk of conversion to MS than CIS below this value. The [Formula: see text] index correlated with positive OCGBs, IgG index above 0.56 and MRI criteria. SAGE Publications 2015-12-16 /pmc/articles/PMC5433434/ /pubmed/28607709 http://dx.doi.org/10.1177/2055217315620935 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Menéndez-Valladares, P García-Sánchez, MI Cuadri Benítez, P Lucas, M Adorna Martínez, M Carranco Galán, V García De Veas Silva, JL Bermudo Guitarte, C Izquierdo Ayuso, G Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title | Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title_full | Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title_fullStr | Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title_full_unstemmed | Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title_short | Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
title_sort | free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433434/ https://www.ncbi.nlm.nih.gov/pubmed/28607709 http://dx.doi.org/10.1177/2055217315620935 |
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