Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

The bat coronavirus HKU4 belongs to the same 2c lineage as that of the deadly Middle East Respiratory Syndrome coronavirus (MERS-CoV) and shows high sequence similarity, therefore potentiating a threat to the human population through a zoonotic shift or ‘spill over’ event. To date, there are no effe...

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Detalles Bibliográficos
Autores principales: St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., Mesecar, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433438/
https://www.ncbi.nlm.nih.gov/pubmed/26190463
http://dx.doi.org/10.1016/j.bmc.2015.06.039

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