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Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS
OBJECTIVE: The objective of this article is to determine the functional brain correlates of information processing speed in multiple sclerosis (MS) patients who smoke cannabis and those who are drug naïve. METHODS: Two neurologically and demographically matched samples of MS patients were enrolled,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433500/ https://www.ncbi.nlm.nih.gov/pubmed/28607694 http://dx.doi.org/10.1177/2055217315588223 |
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author | Pavisian, Bennis Staines, W Richard Feinstein, Anthony |
author_facet | Pavisian, Bennis Staines, W Richard Feinstein, Anthony |
author_sort | Pavisian, Bennis |
collection | PubMed |
description | OBJECTIVE: The objective of this article is to determine the functional brain correlates of information processing speed in multiple sclerosis (MS) patients who smoke cannabis and those who are drug naïve. METHODS: Two neurologically and demographically matched samples of MS patients were enrolled, those who smoked cannabis daily (n = 20) and those who were cannabis naïve (n = 19). All participants completed the Brief Repeatable Battery of Neuropsychological Tests and underwent fMRI testing during which they were administered a modified version of the Symbol Digit Modalities Test (mSDMT). RESULTS: The cannabis group responded slower in nine of 11 blocks of the mSDMT (p < 0.001), showing a trend toward a slower response time (p < 0.08), but did not differ in the accuracy of response (p < 0.18). Both groups displayed activation in a prefrontal cortex-parietal network associated with information processing speed. When compared to the cannabis-naïve group, cannabis users showed less activation in the right (p = 0.009) and left (p = 0.001) thalami and increased activation in the anterior cingulate (p = 0.006). CONCLUSION: Regular cannabis use in MS patients is associated with slower information processing speed and a pattern of cerebral activity that differs from cannabis-naïve individuals, most notably in a bilateral reduction of thalamic activity. |
format | Online Article Text |
id | pubmed-5433500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54335002017-06-12 Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS Pavisian, Bennis Staines, W Richard Feinstein, Anthony Mult Scler J Exp Transl Clin Original Article OBJECTIVE: The objective of this article is to determine the functional brain correlates of information processing speed in multiple sclerosis (MS) patients who smoke cannabis and those who are drug naïve. METHODS: Two neurologically and demographically matched samples of MS patients were enrolled, those who smoked cannabis daily (n = 20) and those who were cannabis naïve (n = 19). All participants completed the Brief Repeatable Battery of Neuropsychological Tests and underwent fMRI testing during which they were administered a modified version of the Symbol Digit Modalities Test (mSDMT). RESULTS: The cannabis group responded slower in nine of 11 blocks of the mSDMT (p < 0.001), showing a trend toward a slower response time (p < 0.08), but did not differ in the accuracy of response (p < 0.18). Both groups displayed activation in a prefrontal cortex-parietal network associated with information processing speed. When compared to the cannabis-naïve group, cannabis users showed less activation in the right (p = 0.009) and left (p = 0.001) thalami and increased activation in the anterior cingulate (p = 0.006). CONCLUSION: Regular cannabis use in MS patients is associated with slower information processing speed and a pattern of cerebral activity that differs from cannabis-naïve individuals, most notably in a bilateral reduction of thalamic activity. SAGE Publications 2015-06-01 /pmc/articles/PMC5433500/ /pubmed/28607694 http://dx.doi.org/10.1177/2055217315588223 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Original Article Pavisian, Bennis Staines, W Richard Feinstein, Anthony Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title | Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title_full | Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title_fullStr | Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title_full_unstemmed | Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title_short | Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS |
title_sort | cannabis-induced alterations in brain activation during a test of information processing speed in patients with ms |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433500/ https://www.ncbi.nlm.nih.gov/pubmed/28607694 http://dx.doi.org/10.1177/2055217315588223 |
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