A case of presumed herpes keratouveitis in a patient treated with fingolimod

We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus...

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Autores principales: Ayers, Malissa C, Conway, Devon S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433502/
https://www.ncbi.nlm.nih.gov/pubmed/28607729
http://dx.doi.org/10.1177/2055217316652907
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author Ayers, Malissa C
Conway, Devon S
author_facet Ayers, Malissa C
Conway, Devon S
author_sort Ayers, Malissa C
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description We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation.
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spelling pubmed-54335022017-06-12 A case of presumed herpes keratouveitis in a patient treated with fingolimod Ayers, Malissa C Conway, Devon S Mult Scler J Exp Transl Clin Case Report We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation. SAGE Publications 2016-06-03 /pmc/articles/PMC5433502/ /pubmed/28607729 http://dx.doi.org/10.1177/2055217316652907 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Ayers, Malissa C
Conway, Devon S
A case of presumed herpes keratouveitis in a patient treated with fingolimod
title A case of presumed herpes keratouveitis in a patient treated with fingolimod
title_full A case of presumed herpes keratouveitis in a patient treated with fingolimod
title_fullStr A case of presumed herpes keratouveitis in a patient treated with fingolimod
title_full_unstemmed A case of presumed herpes keratouveitis in a patient treated with fingolimod
title_short A case of presumed herpes keratouveitis in a patient treated with fingolimod
title_sort case of presumed herpes keratouveitis in a patient treated with fingolimod
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433502/
https://www.ncbi.nlm.nih.gov/pubmed/28607729
http://dx.doi.org/10.1177/2055217316652907
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