Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo

UNC-51-like kinase 1 (ULK1) is well-known to initiate autophagy, and the downregulation of ULK1 has been found in most breast cancer tissues. Thus, the activation of ULK1-modulated autophagy could be a promising strategy for breast cancer therapy. In this study, we found that ULK1 was remarkably dow...

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Detalles Bibliográficos
Autores principales: Zhang, Lan, Fu, Leilei, Zhang, Shouyue, Zhang, Jin, Zhao, Yuqian, Zheng, Yaxin, He, Gu, Yang, Shengyong, Ouyang, Liang, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433508/
https://www.ncbi.nlm.nih.gov/pubmed/28553505
http://dx.doi.org/10.1039/c6sc05368h

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