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Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports

There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation h...

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Autores principales: Kojima, Shuji, Tsukimoto, Mitsutoshi, Shimura, Noriko, Koga, Hironobu, Murata, Akishisa, Takara, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433552/
https://www.ncbi.nlm.nih.gov/pubmed/28539853
http://dx.doi.org/10.1177/1559325817697531
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author Kojima, Shuji
Tsukimoto, Mitsutoshi
Shimura, Noriko
Koga, Hironobu
Murata, Akishisa
Takara, Tsuyoshi
author_facet Kojima, Shuji
Tsukimoto, Mitsutoshi
Shimura, Noriko
Koga, Hironobu
Murata, Akishisa
Takara, Tsuyoshi
author_sort Kojima, Shuji
collection PubMed
description There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation hormesis in patients with these diseases. First, a patient with prostate cancer who had undergone surgical resection showed a subsequent increase in prostate-specific antigen (PSA). His PSA value started decreasing immediately after the start of repeated low-dose X-ray irradiation treatment and remained low thereafter. Second, a patient with prostate cancer with bone metastasis was treated with repeated low-dose X-ray irradiation. His PSA level decreased to nearly normal within 3 months after starting the treatment and remained at the low level after the end of hormesis treatment. His bone metastasis almost completely disappeared. Third, a patient with ulcerative colitis showed a slow initial response to repeated low-dose irradiation treatment using various modalities, including drinking radon-containing water, but within 8 months, his swelling and bleeding had completely disappeared. After 1 year, the number of bowel movements had become normal. Interest in the use of radiation hormesis in clinical practice is increasing, and we hope that these case reports will encourage further clinical investigations.
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spelling pubmed-54335522017-05-24 Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports Kojima, Shuji Tsukimoto, Mitsutoshi Shimura, Noriko Koga, Hironobu Murata, Akishisa Takara, Tsuyoshi Dose Response Original Article There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation hormesis in patients with these diseases. First, a patient with prostate cancer who had undergone surgical resection showed a subsequent increase in prostate-specific antigen (PSA). His PSA value started decreasing immediately after the start of repeated low-dose X-ray irradiation treatment and remained low thereafter. Second, a patient with prostate cancer with bone metastasis was treated with repeated low-dose X-ray irradiation. His PSA level decreased to nearly normal within 3 months after starting the treatment and remained at the low level after the end of hormesis treatment. His bone metastasis almost completely disappeared. Third, a patient with ulcerative colitis showed a slow initial response to repeated low-dose irradiation treatment using various modalities, including drinking radon-containing water, but within 8 months, his swelling and bleeding had completely disappeared. After 1 year, the number of bowel movements had become normal. Interest in the use of radiation hormesis in clinical practice is increasing, and we hope that these case reports will encourage further clinical investigations. SAGE Publications 2017-03-23 /pmc/articles/PMC5433552/ /pubmed/28539853 http://dx.doi.org/10.1177/1559325817697531 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Kojima, Shuji
Tsukimoto, Mitsutoshi
Shimura, Noriko
Koga, Hironobu
Murata, Akishisa
Takara, Tsuyoshi
Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title_full Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title_fullStr Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title_full_unstemmed Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title_short Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports
title_sort treatment of cancer and inflammation with low-dose ionizing radiation: three case reports
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433552/
https://www.ncbi.nlm.nih.gov/pubmed/28539853
http://dx.doi.org/10.1177/1559325817697531
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