Alteration of protein function by a silent polymorphism linked to tRNA abundance

Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids. We identified an sSNP that modifies the local translation speed of the cystic fibrosis transmembrane conductance regulator (CFTR), leading to d...

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Detalles Bibliográficos
Autores principales: Kirchner, Sebastian, Cai, Zhiwei, Rauscher, Robert, Kastelic, Nicolai, Anding, Melanie, Czech, Andreas, Kleizen, Bertrand, Ostedgaard, Lynda S., Braakman, Ineke, Sheppard, David N., Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433685/
https://www.ncbi.nlm.nih.gov/pubmed/28510592
http://dx.doi.org/10.1371/journal.pbio.2000779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433685/
https://www.ncbi.nlm.nih.gov/pubmed/28510592
http://dx.doi.org/10.1371/journal.pbio.2000779

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