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Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study
OBJECTIVE: To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. METHODS: In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433713/ https://www.ncbi.nlm.nih.gov/pubmed/28510594 http://dx.doi.org/10.1371/journal.pone.0177118 |
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author | Magnusson, Karin Bech Holte, Kristine Juel, Niels Gunnar Brox, Jens Ivar Hagen, Kåre Birger Haugen, Ida Kristin Berg, Tore Julsrud |
author_facet | Magnusson, Karin Bech Holte, Kristine Juel, Niels Gunnar Brox, Jens Ivar Hagen, Kåre Birger Haugen, Ida Kristin Berg, Tore Julsrud |
author_sort | Magnusson, Karin |
collection | PubMed |
description | OBJECTIVE: To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. METHODS: In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA(1c): 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA(1c) were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63.0 [7.0], mean [SD] HbA(1c): 5.41 [0.32], N = 29 [42%] men). The groups were compared for radiographic hand OA (Kellgren-Lawrence grade ≥2 in ≥1 joint) and erosive hand OA (central erosions in ≥1 joint), Australian/Canadian index (AUSCAN) for hand pain, disability and stiffness using regression analyses adjusted for age, sex, educational level and waist circumference. RESULTS: We found no associations between having long term type 1 diabetes and more prevalent radiographic hand OA (OR = 0.83, 95% CI = 0.38–1.81). We found a trend towards higher prevalence of erosive hand OA in diabetes patients (OR = 2.96, 95% CI = 0.82–10.64). Strong and consistent associations were observed between long term type 1 diabetes and increased hand pain (B = 2.78, 95% CI = 1.65–3.91), disability (B = 5.30, 95% CI = 3.48–7.12) and stiffness (B = 2.00, 95% CI = 1.33–2.67). These associations were particularly strong for women and participants below the median age of 61 years. CONCLUSION: Long-term type 1 diabetes was not associated with radiographic hand OA, but was strongly associated with hand pain, disability and stiffness. The association between diabetes and erosive hand OA warrants further investigation. |
format | Online Article Text |
id | pubmed-5433713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54337132017-05-26 Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study Magnusson, Karin Bech Holte, Kristine Juel, Niels Gunnar Brox, Jens Ivar Hagen, Kåre Birger Haugen, Ida Kristin Berg, Tore Julsrud PLoS One Research Article OBJECTIVE: To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. METHODS: In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA(1c): 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA(1c) were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63.0 [7.0], mean [SD] HbA(1c): 5.41 [0.32], N = 29 [42%] men). The groups were compared for radiographic hand OA (Kellgren-Lawrence grade ≥2 in ≥1 joint) and erosive hand OA (central erosions in ≥1 joint), Australian/Canadian index (AUSCAN) for hand pain, disability and stiffness using regression analyses adjusted for age, sex, educational level and waist circumference. RESULTS: We found no associations between having long term type 1 diabetes and more prevalent radiographic hand OA (OR = 0.83, 95% CI = 0.38–1.81). We found a trend towards higher prevalence of erosive hand OA in diabetes patients (OR = 2.96, 95% CI = 0.82–10.64). Strong and consistent associations were observed between long term type 1 diabetes and increased hand pain (B = 2.78, 95% CI = 1.65–3.91), disability (B = 5.30, 95% CI = 3.48–7.12) and stiffness (B = 2.00, 95% CI = 1.33–2.67). These associations were particularly strong for women and participants below the median age of 61 years. CONCLUSION: Long-term type 1 diabetes was not associated with radiographic hand OA, but was strongly associated with hand pain, disability and stiffness. The association between diabetes and erosive hand OA warrants further investigation. Public Library of Science 2017-05-16 /pmc/articles/PMC5433713/ /pubmed/28510594 http://dx.doi.org/10.1371/journal.pone.0177118 Text en © 2017 Magnusson et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Magnusson, Karin Bech Holte, Kristine Juel, Niels Gunnar Brox, Jens Ivar Hagen, Kåre Birger Haugen, Ida Kristin Berg, Tore Julsrud Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title | Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title_full | Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title_fullStr | Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title_full_unstemmed | Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title_short | Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study |
title_sort | long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – the dialong hand study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433713/ https://www.ncbi.nlm.nih.gov/pubmed/28510594 http://dx.doi.org/10.1371/journal.pone.0177118 |
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