Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: Mechanisms of lipotoxicity

BACKGROUND AND AIM: Fatty acids acutely stimulate GLP-1 secretion from L-cells in vivo. However, a high fat diet has been shown to reduce the density of L-cells in the mouse intestine and a positive correlation has been indicated between L-cell number and GLP-1 secretion. Thus, the mechanism of fatt...

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Detalles Bibliográficos
Autores principales: Thombare, Ketan, Ntika, Stelia, Wang, Xuan, Krizhanovskii, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433723/
https://www.ncbi.nlm.nih.gov/pubmed/28520810
http://dx.doi.org/10.1371/journal.pone.0177605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433723/
https://www.ncbi.nlm.nih.gov/pubmed/28520810
http://dx.doi.org/10.1371/journal.pone.0177605

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