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Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening

PURPOSE: We studied the validity, usefulness, and relative cost to detect diabetic retinopathy (DR) and sight-threatening DR (STDR) by using a hand-held electrophysiologic tool compared to digital fundus photography. METHOD: Patients with diabetes attending the screening unit of King Khaled Eye Spec...

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Autores principales: Al-Otaibi, Humoud, Al-Otaibi, Mohammed D., Khandekar, Rajiv, Souru, Ches, Al-Abdullah, Abdulelah A., Al-Dhibi, Hassan, Stone, Donald U., Kozak, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433802/
https://www.ncbi.nlm.nih.gov/pubmed/28516001
http://dx.doi.org/10.1167/tvst.6.3.3
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author Al-Otaibi, Humoud
Al-Otaibi, Mohammed D.
Khandekar, Rajiv
Souru, Ches
Al-Abdullah, Abdulelah A.
Al-Dhibi, Hassan
Stone, Donald U.
Kozak, Igor
author_facet Al-Otaibi, Humoud
Al-Otaibi, Mohammed D.
Khandekar, Rajiv
Souru, Ches
Al-Abdullah, Abdulelah A.
Al-Dhibi, Hassan
Stone, Donald U.
Kozak, Igor
author_sort Al-Otaibi, Humoud
collection PubMed
description PURPOSE: We studied the validity, usefulness, and relative cost to detect diabetic retinopathy (DR) and sight-threatening DR (STDR) by using a hand-held electrophysiologic tool compared to digital fundus photography. METHOD: Patients with diabetes attending the screening unit of King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia were evaluated by “RETeval”, Amsler grid, and digital dilated fundus photography. Fundus images were evaluated by a retina specialist to determine grade of DR. The sensitivity and specificity of STDR and DR screening compared to photography were calculated, as well as “RETeval” combined with Amsler grid testing. The area under the curve (AUC) of “RETeval” screening outcome was calculated. RESULT: We analyzed data of 400 diabetic patients. The prevalence of DR of any grade was 48.8% (95% confidence interval [CI], 43.9–53.7) while the prevalence of STDR was 27% (95% CI, 22.6–31.4). The outcome of RETeval test was “fail” (based on 20 μV or more amplitude of electrophysiologic spikes) in 351 (87.8%; 95% CI, 84.5–91.0) eyes. The sensitivity of the device was 95.4% and the specificity was 17.5%. Thus, the sensitivity of sequential testing with RETeval and Amsler grid test was 30.1% and the specificity was 80.1%. The AUCs for STDR and DR in general were 76.6% and 50.6%, respectively. CONCLUSIONS: “RETeval” is a rapid screening device with excellent sensitivity for detecting STDR. It has potential as a first level screening tool to detect patients who require further evaluation. TRANSLATIONAL RELEVANCE: Retinal function, such as electrophysiology, can be used as a new concept for screening for DR.
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spelling pubmed-54338022017-05-17 Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening Al-Otaibi, Humoud Al-Otaibi, Mohammed D. Khandekar, Rajiv Souru, Ches Al-Abdullah, Abdulelah A. Al-Dhibi, Hassan Stone, Donald U. Kozak, Igor Transl Vis Sci Technol Articles PURPOSE: We studied the validity, usefulness, and relative cost to detect diabetic retinopathy (DR) and sight-threatening DR (STDR) by using a hand-held electrophysiologic tool compared to digital fundus photography. METHOD: Patients with diabetes attending the screening unit of King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia were evaluated by “RETeval”, Amsler grid, and digital dilated fundus photography. Fundus images were evaluated by a retina specialist to determine grade of DR. The sensitivity and specificity of STDR and DR screening compared to photography were calculated, as well as “RETeval” combined with Amsler grid testing. The area under the curve (AUC) of “RETeval” screening outcome was calculated. RESULT: We analyzed data of 400 diabetic patients. The prevalence of DR of any grade was 48.8% (95% confidence interval [CI], 43.9–53.7) while the prevalence of STDR was 27% (95% CI, 22.6–31.4). The outcome of RETeval test was “fail” (based on 20 μV or more amplitude of electrophysiologic spikes) in 351 (87.8%; 95% CI, 84.5–91.0) eyes. The sensitivity of the device was 95.4% and the specificity was 17.5%. Thus, the sensitivity of sequential testing with RETeval and Amsler grid test was 30.1% and the specificity was 80.1%. The AUCs for STDR and DR in general were 76.6% and 50.6%, respectively. CONCLUSIONS: “RETeval” is a rapid screening device with excellent sensitivity for detecting STDR. It has potential as a first level screening tool to detect patients who require further evaluation. TRANSLATIONAL RELEVANCE: Retinal function, such as electrophysiology, can be used as a new concept for screening for DR. The Association for Research in Vision and Ophthalmology 2017-05-16 /pmc/articles/PMC5433802/ /pubmed/28516001 http://dx.doi.org/10.1167/tvst.6.3.3 Text en Copyright 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Al-Otaibi, Humoud
Al-Otaibi, Mohammed D.
Khandekar, Rajiv
Souru, Ches
Al-Abdullah, Abdulelah A.
Al-Dhibi, Hassan
Stone, Donald U.
Kozak, Igor
Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title_full Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title_fullStr Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title_full_unstemmed Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title_short Validity, Usefulness and Cost of RETeval System for Diabetic Retinopathy Screening
title_sort validity, usefulness and cost of reteval system for diabetic retinopathy screening
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433802/
https://www.ncbi.nlm.nih.gov/pubmed/28516001
http://dx.doi.org/10.1167/tvst.6.3.3
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