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Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia
Genetic alterations initiate tumors and enable the evolution of drug resistance. The pro-cancer view of mutations is however incomplete, and several studies show that mutational load can reduce tumor fitness. Given its negative effect, genetic load should make tumors more sensitive to anticancer dru...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434051/ https://www.ncbi.nlm.nih.gov/pubmed/28512298 http://dx.doi.org/10.1038/s41598-017-02178-1 |