MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes

Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimmunity. Studies have recently shown variations in genes encodi...

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Autores principales: Zurawek, Magdalena, Fichna, Marta, Kazimierska, Marta, Fichna, Piotr, Dzikiewicz-Krawczyk, Agnieszka, Przybylski, Grzegorz, Ruchala, Marek, Nowak, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434126/
https://www.ncbi.nlm.nih.gov/pubmed/27652379
http://dx.doi.org/10.1007/s00005-016-0426-6
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author Zurawek, Magdalena
Fichna, Marta
Kazimierska, Marta
Fichna, Piotr
Dzikiewicz-Krawczyk, Agnieszka
Przybylski, Grzegorz
Ruchala, Marek
Nowak, Jerzy
author_facet Zurawek, Magdalena
Fichna, Marta
Kazimierska, Marta
Fichna, Piotr
Dzikiewicz-Krawczyk, Agnieszka
Przybylski, Grzegorz
Ruchala, Marek
Nowak, Jerzy
author_sort Zurawek, Magdalena
collection PubMed
description Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimmunity. Studies have recently shown variations in genes encoding RLRs as risk factors for autoimmune diseases. We investigated whether MAVS coding polymorphisms are associated with Addison’s disease (AD) and type 1 diabetes (T1D) in Polish population. We genotyped 140 AD, 532 T1D patients and 600 healthy controls for MAVS rs17857295, rs7262903, rs45437096 and rs7269320. Genotyping was performed by TaqMan assays. Distribution of the MAVS genotypes and alleles did not reveal significant differences between patients and controls (p > 0.05). This analysis did not indicate the association of the MAVS locus with susceptibility to AD and T1D.
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spelling pubmed-54341262017-05-31 MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes Zurawek, Magdalena Fichna, Marta Kazimierska, Marta Fichna, Piotr Dzikiewicz-Krawczyk, Agnieszka Przybylski, Grzegorz Ruchala, Marek Nowak, Jerzy Arch Immunol Ther Exp (Warsz) Short Communication Mitochondrial antiviral signaling (MAVS) protein is an intracellular adaptor molecule, downstream of viral sensors, retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs). Impaired antiviral cell signaling might contribute to autoimmunity. Studies have recently shown variations in genes encoding RLRs as risk factors for autoimmune diseases. We investigated whether MAVS coding polymorphisms are associated with Addison’s disease (AD) and type 1 diabetes (T1D) in Polish population. We genotyped 140 AD, 532 T1D patients and 600 healthy controls for MAVS rs17857295, rs7262903, rs45437096 and rs7269320. Genotyping was performed by TaqMan assays. Distribution of the MAVS genotypes and alleles did not reveal significant differences between patients and controls (p > 0.05). This analysis did not indicate the association of the MAVS locus with susceptibility to AD and T1D. Springer International Publishing 2016-09-20 2017 /pmc/articles/PMC5434126/ /pubmed/27652379 http://dx.doi.org/10.1007/s00005-016-0426-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Zurawek, Magdalena
Fichna, Marta
Kazimierska, Marta
Fichna, Piotr
Dzikiewicz-Krawczyk, Agnieszka
Przybylski, Grzegorz
Ruchala, Marek
Nowak, Jerzy
MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title_full MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title_fullStr MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title_full_unstemmed MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title_short MAVS is not a Likely Susceptibility Locus for Addison’s Disease and Type 1 Diabetes
title_sort mavs is not a likely susceptibility locus for addison’s disease and type 1 diabetes
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434126/
https://www.ncbi.nlm.nih.gov/pubmed/27652379
http://dx.doi.org/10.1007/s00005-016-0426-6
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