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Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population

Purpose. This study was performed to evaluate the relationship between intraocular pressure (IOP) and glaucomatous optic nerve change and thyroid factors in Korean population. Materials and Methods. The study included subjects who underwent health screening in Kangbuk Samsung Hospital. Detailed hist...

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Autores principales: Won, Yu Sam, Kim, Da Yeong, Kim, Joon Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434236/
https://www.ncbi.nlm.nih.gov/pubmed/28553551
http://dx.doi.org/10.1155/2017/8280209
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author Won, Yu Sam
Kim, Da Yeong
Kim, Joon Mo
author_facet Won, Yu Sam
Kim, Da Yeong
Kim, Joon Mo
author_sort Won, Yu Sam
collection PubMed
description Purpose. This study was performed to evaluate the relationship between intraocular pressure (IOP) and glaucomatous optic nerve change and thyroid factors in Korean population. Materials and Methods. The study included subjects who underwent health screening in Kangbuk Samsung Hospital. Detailed history taking and systemic and ocular examination including fundus photography were performed for all participants. All fundus photographs were divided into two groups based on disc and RNFL appearance: nonglaucoma and glaucoma group. Subjects were also divided into quartiles of each thyroid function parameter, and the relationship with IOP and glaucoma were analysed. Results. In univariate analysis, free T4, T3, and TSH in normal subjects and T3 in thyroid disease group were associated with the IOP. After adjusting for age and sex, the IOP tended to slightly decrease according to the level of the quartile of free T4 and T3 in normal subjects. In terms of glaucoma, on multivariate analysis, it did not show a significant correlation with any thyroid function tests. Conclusions. In normal subjects, the IOP tended to be decreased according to the level of free T4 and T3 but the amounts were clinically insignificant. Thyroid factors are not an independent risk factor for the development of glaucoma.
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spelling pubmed-54342362017-05-28 Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population Won, Yu Sam Kim, Da Yeong Kim, Joon Mo J Ophthalmol Research Article Purpose. This study was performed to evaluate the relationship between intraocular pressure (IOP) and glaucomatous optic nerve change and thyroid factors in Korean population. Materials and Methods. The study included subjects who underwent health screening in Kangbuk Samsung Hospital. Detailed history taking and systemic and ocular examination including fundus photography were performed for all participants. All fundus photographs were divided into two groups based on disc and RNFL appearance: nonglaucoma and glaucoma group. Subjects were also divided into quartiles of each thyroid function parameter, and the relationship with IOP and glaucoma were analysed. Results. In univariate analysis, free T4, T3, and TSH in normal subjects and T3 in thyroid disease group were associated with the IOP. After adjusting for age and sex, the IOP tended to slightly decrease according to the level of the quartile of free T4 and T3 in normal subjects. In terms of glaucoma, on multivariate analysis, it did not show a significant correlation with any thyroid function tests. Conclusions. In normal subjects, the IOP tended to be decreased according to the level of free T4 and T3 but the amounts were clinically insignificant. Thyroid factors are not an independent risk factor for the development of glaucoma. Hindawi 2017 2017-05-02 /pmc/articles/PMC5434236/ /pubmed/28553551 http://dx.doi.org/10.1155/2017/8280209 Text en Copyright © 2017 Yu Sam Won et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Won, Yu Sam
Kim, Da Yeong
Kim, Joon Mo
Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title_full Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title_fullStr Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title_full_unstemmed Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title_short Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
title_sort glaucomatous optic nerve changes and thyroid dysfunction in an urban south korean population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434236/
https://www.ncbi.nlm.nih.gov/pubmed/28553551
http://dx.doi.org/10.1155/2017/8280209
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