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Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study

Objectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, C...

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Autores principales: Magalhães, Rafael Coelho, Moreira, Janaina Matos, Vieira, Érica Leandro Marciano, Rocha, Natália Pessoa, Miranda, Débora Marques, Simões e Silva, Ana Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434239/
https://www.ncbi.nlm.nih.gov/pubmed/28553016
http://dx.doi.org/10.1155/2017/8201423
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author Magalhães, Rafael Coelho
Moreira, Janaina Matos
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Miranda, Débora Marques
Simões e Silva, Ana Cristina
author_facet Magalhães, Rafael Coelho
Moreira, Janaina Matos
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Miranda, Débora Marques
Simões e Silva, Ana Cristina
author_sort Magalhães, Rafael Coelho
collection PubMed
description Objectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG), and neurotrophic factors (BDNF and GDNF) were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood) (T0), at 48 (T1), at 72 hours (T2), and at 3 weeks after birth (T3). Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP) percentiles. Results. Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development. Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development. Conclusion. Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates.
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spelling pubmed-54342392017-05-28 Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study Magalhães, Rafael Coelho Moreira, Janaina Matos Vieira, Érica Leandro Marciano Rocha, Natália Pessoa Miranda, Débora Marques Simões e Silva, Ana Cristina Mediators Inflamm Research Article Objectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG), and neurotrophic factors (BDNF and GDNF) were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood) (T0), at 48 (T1), at 72 hours (T2), and at 3 weeks after birth (T3). Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP) percentiles. Results. Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development. Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development. Conclusion. Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates. Hindawi 2017 2017-05-02 /pmc/articles/PMC5434239/ /pubmed/28553016 http://dx.doi.org/10.1155/2017/8201423 Text en Copyright © 2017 Rafael Coelho Magalhães et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Magalhães, Rafael Coelho
Moreira, Janaina Matos
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Miranda, Débora Marques
Simões e Silva, Ana Cristina
Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title_full Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title_fullStr Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title_full_unstemmed Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title_short Urinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Study
title_sort urinary levels of il-1β and gdnf in preterm neonates as potential biomarkers of motor development: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434239/
https://www.ncbi.nlm.nih.gov/pubmed/28553016
http://dx.doi.org/10.1155/2017/8201423
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