Cargando…

HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway

Amyloid beta (Aβ) deposition is increased in human immunodeficiency virus-1- (HIV-1-) infected brain, but the mechanisms are not fully understood. The aim of the present study was to evaluate the role of Ras signaling in HIV-1 transactivator protein- (Tat-) induced Aβ accumulation in human cerebral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Wenlin, Huang, Wen, Chen, Yanlan, Zou, Min, Peng, Dingyue, Chen, Debing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434241/ https://www.ncbi.nlm.nih.gov/pubmed/28553432 http://dx.doi.org/10.1155/2017/3160360

Ejemplares similares

HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway
por: Chen, Yanlan, et al.
Publicado: (2016)

Cingulin Contains Globular and Coiled-Coil Domains and Interacts with Zo-1, Zo-2, Zo-3, and Myosin
por: Cordenonsi, Michelangelo, et al.
Publicado: (1999)

Anagliptin Protected against Hypoxia/Reperfusion-Induced Brain Vascular Endothelial Permeability by Increasing ZO-1
por: Li, Chuo, et al.
Publicado: (2021)

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO-1/ZONAB pathway
por: He, Lixian, et al.
Publicado: (2018)

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins
por: Itoh, Masahiko, et al.
Publicado: (1999)

Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway
por: Zou, Peicen, et al.
Publicado: (2022)

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells
por: Yamamoto, Takaharu, et al.
Publicado: (1997)

Scutellarin-treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells
por: Zhong, Xiaoqin, et al.
Publicado: (2019)

Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin
por: Chen, Horng H., et al.
Publicado: (2020)

Angiotensin II Receptor–Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats
por: Seki, Takunori, et al.
Publicado: (2017)

Rho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels
por: Chen, Qiangtang, et al.
Publicado: (2021)

Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats
por: Polina, Iuliia, et al.
Publicado: (2021)

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation
por: Tornavaca, Olga, et al.
Publicado: (2015)

Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions
por: Maciel, Rayana A. P., et al.
Publicado: (2018)

Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier
por: Branca, Jacopo Junio Valerio, et al.
Publicado: (2019)

Role of Cav-1 in HIV-1 Tat-Induced Dysfunction of Tight Junctions and Aβ-Transferring Proteins
por: Zou, Min, et al.
Publicado: (2019)

ZO-1 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Involvement of ZO-1 in the Regulation of Cytoskeleton and Cell Shape
por: Tokuda, Shinsaku, et al.
Publicado: (2014)

R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
por: Rouaud, Florian, et al.
Publicado: (2019)

ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells
por: Wang, Lan, et al.
Publicado: (2022)

The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila
por: Sang, Qingliang, et al.
Publicado: (2021)

Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression
por: Wang, Meng, et al.
Publicado: (2018)

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin
por: Haskins, Julie, et al.
Publicado: (1998)

Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster
por: Meyer, Heiko, et al.
Publicado: (2021)

BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation
por: Khan, Nabab, et al.
Publicado: (2019)

Tight junction protein ZO-1 in Kawasaki disease
por: Lai, Wan-Tz, et al.
Publicado: (2021)

Het is zo stil
por: Wijdeveld, Mechtild
Publicado: (2020)

Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin
por: Zeng, Xiangliang, et al.
Publicado: (2022)

Neprilysin Inhibitors and Bradykinin
por: Campbell, Duncan J.
Publicado: (2018)

Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation
por: Khan, Nabab, et al.
Publicado: (2018)

GNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer
por: Kim, Hyung Seok, et al.
Publicado: (2023)

MicroRNA-103 regulates the progression in endometrial carcinoma through ZO-1
por: Du, Jing, et al.
Publicado: (2019)

Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease
por: Wang, Jun, et al.
Publicado: (2016)

Brain Shuttle Neprilysin reduces central Amyloid-β levels
por: Campos, Christopher R., et al.
Publicado: (2020)

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena
por: AlAnazi, Faisal Holil, et al.
Publicado: (2023)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome
por: Canudas, Jesús, et al.
Publicado: (2014)

B* Production in Zo decays
por: Schael, S, et al.
Publicado: (1994)

Zo min mogelijk contact
por: Broersma, Simon
Publicado: (2020)

Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat
por: Muniz, Lisa, et al.
Publicado: (2010)

Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA
por: Mahajan, Supriya D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_s9elnj4h6lriuh8hr609b4j4e1