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HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway

Amyloid beta (Aβ) deposition is increased in human immunodeficiency virus-1- (HIV-1-) infected brain, but the mechanisms are not fully understood. The aim of the present study was to evaluate the role of Ras signaling in HIV-1 transactivator protein- (Tat-) induced Aβ accumulation in human cerebral...

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Detalles Bibliográficos
Autores principales:	Jiang, Wenlin, Huang, Wen, Chen, Yanlan, Zou, Min, Peng, Dingyue, Chen, Debing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434241/ https://www.ncbi.nlm.nih.gov/pubmed/28553432 http://dx.doi.org/10.1155/2017/3160360

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