The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism

Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile infl...

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Detalles Bibliográficos
Autores principales: Farrugia, Mark, Baron, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434307/
https://www.ncbi.nlm.nih.gov/pubmed/28553556
http://dx.doi.org/10.1155/2017/8391230
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author Farrugia, Mark
Baron, Byron
author_facet Farrugia, Mark
Baron, Byron
author_sort Farrugia, Mark
collection PubMed
description Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity.
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spelling pubmed-54343072017-05-28 The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism Farrugia, Mark Baron, Byron Int J Inflam Review Article Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity. Hindawi 2017 2017-05-03 /pmc/articles/PMC5434307/ /pubmed/28553556 http://dx.doi.org/10.1155/2017/8391230 Text en Copyright © 2017 Mark Farrugia and Byron Baron. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Farrugia, Mark
Baron, Byron
The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title_full The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title_fullStr The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title_full_unstemmed The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title_short The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
title_sort role of toll-like receptors in autoimmune diseases through failure of the self-recognition mechanism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434307/
https://www.ncbi.nlm.nih.gov/pubmed/28553556
http://dx.doi.org/10.1155/2017/8391230
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