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A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels
BACKGROUND: Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information. With whole-genome sequence (WGS) data, relatively small samples of referen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434521/ https://www.ncbi.nlm.nih.gov/pubmed/28511677 http://dx.doi.org/10.1186/s12711-017-0321-6 |