Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved

Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neur...

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Detalles Bibliográficos
Autores principales: Afelik, Solomon, Rovira, Meritxell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434582/
https://www.ncbi.nlm.nih.gov/pubmed/28511717
http://dx.doi.org/10.1186/s13073-017-0437-x
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author Afelik, Solomon
Rovira, Meritxell
author_facet Afelik, Solomon
Rovira, Meritxell
author_sort Afelik, Solomon
collection PubMed
description Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neurogenin-3.
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spelling pubmed-54345822017-05-18 Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved Afelik, Solomon Rovira, Meritxell Genome Med Comment Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neurogenin-3. BioMed Central 2017-05-16 /pmc/articles/PMC5434582/ /pubmed/28511717 http://dx.doi.org/10.1186/s13073-017-0437-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Afelik, Solomon
Rovira, Meritxell
Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title_full Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title_fullStr Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title_full_unstemmed Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title_short Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
title_sort pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434582/
https://www.ncbi.nlm.nih.gov/pubmed/28511717
http://dx.doi.org/10.1186/s13073-017-0437-x
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