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Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria

BACKGROUND: Magnesium (Mg) is the 4(th) most common mineral and the 2(nd) most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states. AIM: The aim of this study was to study the patterns and correlates of se...

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Autores principales: Odusan, Olatunde O., Familoni, Oluranti Babatope, Odewabi, Adesina O., Idowu, Akolade O., Adekolade, Ayodeji S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434730/
https://www.ncbi.nlm.nih.gov/pubmed/28553602
http://dx.doi.org/10.4103/ijem.IJEM_190_16
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author Odusan, Olatunde O.
Familoni, Oluranti Babatope
Odewabi, Adesina O.
Idowu, Akolade O.
Adekolade, Ayodeji S.
author_facet Odusan, Olatunde O.
Familoni, Oluranti Babatope
Odewabi, Adesina O.
Idowu, Akolade O.
Adekolade, Ayodeji S.
author_sort Odusan, Olatunde O.
collection PubMed
description BACKGROUND: Magnesium (Mg) is the 4(th) most common mineral and the 2(nd) most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states. AIM: The aim of this study was to study the patterns and correlates of serum Mg in cohorts of type 2 diabetic patients in Nigeria. SUBJECTS AND METHODS: One hundred and twenty-five patients comprising 63 with type 2 diabetes mellitus (T2DM) alone and 62 with diabetes and hypertension (HT) were compared with fifty controls matched for sex and age. Basic data, HbA1c, and fasting blood glucose (FBG) were obtained while serum Mg was measured by colorimeter. Relationship between serum Mg and glucose control was considered while serum Mg < 1.6 mg/dl was considered as hypomagnesemia. RESULTS: The mean serum Mg of all patients was 2.06 ± 0.49 mg/dl, not statistically different from controls at 2.22 ± 0.48 mg/dl. About ¼ (23.2%) of the patients had hypomagnesemia which was significantly more than 12% of controls. Although the patients with diabetes and HT were older and more of females than those with DM alone, the mean serum Mg was comparable (2.03 ± 0.49 vs. 2.09 + 0.50 mg/dl). Twenty-seven percent (27%) of patients who had DM alone was more than 19.3% with HT and diabetes combined. Whereas the FBG was comparable in patients with hypomagnesemia and normal serum Mg, HbA1c was significantly higher in the hypomagnesemia group (8.39 ± 0.98 vs. 6.75 ± 1.22%, P = 0.021). CONCLUSION: Hypomagnesemia is common in T2DM outpatients occurring approximately one in four patients. It is associated with poor long-term control.
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spelling pubmed-54347302017-05-26 Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria Odusan, Olatunde O. Familoni, Oluranti Babatope Odewabi, Adesina O. Idowu, Akolade O. Adekolade, Ayodeji S. Indian J Endocrinol Metab Original Article BACKGROUND: Magnesium (Mg) is the 4(th) most common mineral and the 2(nd) most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states. AIM: The aim of this study was to study the patterns and correlates of serum Mg in cohorts of type 2 diabetic patients in Nigeria. SUBJECTS AND METHODS: One hundred and twenty-five patients comprising 63 with type 2 diabetes mellitus (T2DM) alone and 62 with diabetes and hypertension (HT) were compared with fifty controls matched for sex and age. Basic data, HbA1c, and fasting blood glucose (FBG) were obtained while serum Mg was measured by colorimeter. Relationship between serum Mg and glucose control was considered while serum Mg < 1.6 mg/dl was considered as hypomagnesemia. RESULTS: The mean serum Mg of all patients was 2.06 ± 0.49 mg/dl, not statistically different from controls at 2.22 ± 0.48 mg/dl. About ¼ (23.2%) of the patients had hypomagnesemia which was significantly more than 12% of controls. Although the patients with diabetes and HT were older and more of females than those with DM alone, the mean serum Mg was comparable (2.03 ± 0.49 vs. 2.09 + 0.50 mg/dl). Twenty-seven percent (27%) of patients who had DM alone was more than 19.3% with HT and diabetes combined. Whereas the FBG was comparable in patients with hypomagnesemia and normal serum Mg, HbA1c was significantly higher in the hypomagnesemia group (8.39 ± 0.98 vs. 6.75 ± 1.22%, P = 0.021). CONCLUSION: Hypomagnesemia is common in T2DM outpatients occurring approximately one in four patients. It is associated with poor long-term control. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5434730/ /pubmed/28553602 http://dx.doi.org/10.4103/ijem.IJEM_190_16 Text en Copyright: © 2017 Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Odusan, Olatunde O.
Familoni, Oluranti Babatope
Odewabi, Adesina O.
Idowu, Akolade O.
Adekolade, Ayodeji S.
Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title_full Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title_fullStr Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title_full_unstemmed Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title_short Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria
title_sort patterns and correlates of serum magnesium levels in subsets of type 2 diabetes mellitus patients in nigeria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434730/
https://www.ncbi.nlm.nih.gov/pubmed/28553602
http://dx.doi.org/10.4103/ijem.IJEM_190_16
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