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The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort

OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross‐sectional study using UK Biobank data (n = 502 642). Psychiatric an...

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Autores principales: Cullen, B., Smith, D. J., Deary, I. J., Evans, J. J., Pell, J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434825/
https://www.ncbi.nlm.nih.gov/pubmed/28387438
http://dx.doi.org/10.1111/acps.12733
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author Cullen, B.
Smith, D. J.
Deary, I. J.
Evans, J. J.
Pell, J. P.
author_facet Cullen, B.
Smith, D. J.
Deary, I. J.
Evans, J. J.
Pell, J. P.
author_sort Cullen, B.
collection PubMed
description OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross‐sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self‐reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data. RESULTS: Relative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in multiple sclerosis and Parkinson's disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100 000 [95% CI 130, 381]) than for all other disorders. CONCLUSION: Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group.
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spelling pubmed-54348252017-06-01 The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort Cullen, B. Smith, D. J. Deary, I. J. Evans, J. J. Pell, J. P. Acta Psychiatr Scand Original Articles OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross‐sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self‐reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data. RESULTS: Relative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in multiple sclerosis and Parkinson's disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100 000 [95% CI 130, 381]) than for all other disorders. CONCLUSION: Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group. John Wiley and Sons Inc. 2017-04-07 2017-06 /pmc/articles/PMC5434825/ /pubmed/28387438 http://dx.doi.org/10.1111/acps.12733 Text en © 2017 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Cullen, B.
Smith, D. J.
Deary, I. J.
Evans, J. J.
Pell, J. P.
The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title_full The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title_fullStr The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title_full_unstemmed The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title_short The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort
title_sort ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the uk biobank cohort
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434825/
https://www.ncbi.nlm.nih.gov/pubmed/28387438
http://dx.doi.org/10.1111/acps.12733
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