Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART

A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as ‘resistant’. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such mar...

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Autores principales: Gubareva, Larisa V, Fallows, Eric, Mishin, Vasiliy P, Hodges, Erin, Brooks, Abdullah, Barnes, John, Fry, Alicia M, Kramp, William, Shively, Roxanne, Wentworth, David E, Weidemaier, Kristin, Jacobson, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434880/
https://www.ncbi.nlm.nih.gov/pubmed/28494845
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.18.30529
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author Gubareva, Larisa V
Fallows, Eric
Mishin, Vasiliy P
Hodges, Erin
Brooks, Abdullah
Barnes, John
Fry, Alicia M
Kramp, William
Shively, Roxanne
Wentworth, David E
Weidemaier, Kristin
Jacobson, Ross
author_facet Gubareva, Larisa V
Fallows, Eric
Mishin, Vasiliy P
Hodges, Erin
Brooks, Abdullah
Barnes, John
Fry, Alicia M
Kramp, William
Shively, Roxanne
Wentworth, David E
Weidemaier, Kristin
Jacobson, Ross
author_sort Gubareva, Larisa V
collection PubMed
description A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as ‘resistant’. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.
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spelling pubmed-54348802017-05-30 Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART Gubareva, Larisa V Fallows, Eric Mishin, Vasiliy P Hodges, Erin Brooks, Abdullah Barnes, John Fry, Alicia M Kramp, William Shively, Roxanne Wentworth, David E Weidemaier, Kristin Jacobson, Ross Euro Surveill Rapid Communication A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as ‘resistant’. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing. European Centre for Disease Prevention and Control (ECDC) 2017-05-04 /pmc/articles/PMC5434880/ /pubmed/28494845 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.18.30529 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Gubareva, Larisa V
Fallows, Eric
Mishin, Vasiliy P
Hodges, Erin
Brooks, Abdullah
Barnes, John
Fry, Alicia M
Kramp, William
Shively, Roxanne
Wentworth, David E
Weidemaier, Kristin
Jacobson, Ross
Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title_full Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title_fullStr Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title_full_unstemmed Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title_short Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART
title_sort monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iart
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434880/
https://www.ncbi.nlm.nih.gov/pubmed/28494845
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.18.30529
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