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Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation

BACKGROUND—: Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping ma...

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Autores principales: Roney, Caroline H., Cantwell, Chris D., Bayer, Jason D., Qureshi, Norman A., Lim, Phang Boon, Tweedy, Jennifer H., Kanagaratnam, Prapa, Peters, Nicholas S., Vigmond, Edward J., Ng, Fu Siong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434962/
https://www.ncbi.nlm.nih.gov/pubmed/28500175
http://dx.doi.org/10.1161/CIRCEP.116.004899
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author Roney, Caroline H.
Cantwell, Chris D.
Bayer, Jason D.
Qureshi, Norman A.
Lim, Phang Boon
Tweedy, Jennifer H.
Kanagaratnam, Prapa
Peters, Nicholas S.
Vigmond, Edward J.
Ng, Fu Siong
author_facet Roney, Caroline H.
Cantwell, Chris D.
Bayer, Jason D.
Qureshi, Norman A.
Lim, Phang Boon
Tweedy, Jennifer H.
Kanagaratnam, Prapa
Peters, Nicholas S.
Vigmond, Edward J.
Ng, Fu Siong
author_sort Roney, Caroline H.
collection PubMed
description BACKGROUND—: Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping may lead to misinterpretation of the underlying mechanism in persistent AF. METHODS AND RESULTS—: Simulations of rotors and focal sources were performed to estimate the minimum number of recording points required to correctly identify the underlying AF mechanism. The effects of different data types (action potentials and unipolar or bipolar electrograms) and rotor stability on resolution requirements were investigated. We also determined the ability of clinically used endocardial catheters to identify AF mechanisms using clinically recorded and simulated data. The spatial resolution required for correct identification of rotors and focal sources is a linear function of spatial wavelength (the distance between wavefronts) of the arrhythmia. Rotor localization errors are larger for electrogram data than for action potential data. Stationary rotors are more reliably identified compared with meandering trajectories, for any given spatial resolution. All clinical high-resolution multipolar catheters are of sufficient resolution to accurately detect and track rotors when placed over the rotor core although the low-resolution basket catheter is prone to false detections and may incorrectly identify rotors that are not present. CONCLUSIONS—: The spatial resolution of AF data can significantly affect the interpretation of the underlying AF mechanism. Therefore, the interpretation of human AF data must be taken in the context of the spatial resolution of the recordings.
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spelling pubmed-54349622017-05-23 Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation Roney, Caroline H. Cantwell, Chris D. Bayer, Jason D. Qureshi, Norman A. Lim, Phang Boon Tweedy, Jennifer H. Kanagaratnam, Prapa Peters, Nicholas S. Vigmond, Edward J. Ng, Fu Siong Circ Arrhythm Electrophysiol Original Articles BACKGROUND—: Recent studies have demonstrated conflicting mechanisms underlying atrial fibrillation (AF), with the spatial resolution of data often cited as a potential reason for the disagreement. The purpose of this study was to investigate whether the variation in spatial resolution of mapping may lead to misinterpretation of the underlying mechanism in persistent AF. METHODS AND RESULTS—: Simulations of rotors and focal sources were performed to estimate the minimum number of recording points required to correctly identify the underlying AF mechanism. The effects of different data types (action potentials and unipolar or bipolar electrograms) and rotor stability on resolution requirements were investigated. We also determined the ability of clinically used endocardial catheters to identify AF mechanisms using clinically recorded and simulated data. The spatial resolution required for correct identification of rotors and focal sources is a linear function of spatial wavelength (the distance between wavefronts) of the arrhythmia. Rotor localization errors are larger for electrogram data than for action potential data. Stationary rotors are more reliably identified compared with meandering trajectories, for any given spatial resolution. All clinical high-resolution multipolar catheters are of sufficient resolution to accurately detect and track rotors when placed over the rotor core although the low-resolution basket catheter is prone to false detections and may incorrectly identify rotors that are not present. CONCLUSIONS—: The spatial resolution of AF data can significantly affect the interpretation of the underlying AF mechanism. Therefore, the interpretation of human AF data must be taken in the context of the spatial resolution of the recordings. Lippincott Williams & Wilkins 2017-05 2017-05-16 /pmc/articles/PMC5434962/ /pubmed/28500175 http://dx.doi.org/10.1161/CIRCEP.116.004899 Text en © 2017 The Authors. Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
spellingShingle Original Articles
Roney, Caroline H.
Cantwell, Chris D.
Bayer, Jason D.
Qureshi, Norman A.
Lim, Phang Boon
Tweedy, Jennifer H.
Kanagaratnam, Prapa
Peters, Nicholas S.
Vigmond, Edward J.
Ng, Fu Siong
Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title_full Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title_fullStr Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title_full_unstemmed Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title_short Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation
title_sort spatial resolution requirements for accurate identification of drivers of atrial fibrillation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434962/
https://www.ncbi.nlm.nih.gov/pubmed/28500175
http://dx.doi.org/10.1161/CIRCEP.116.004899
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