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Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease
Understanding the complex mutation patterns that give rise to drug resistant viral strains provides a foundation for developing more effective treatment strategies for HIV/AIDS. Multiple sequence alignments of drug-experienced HIV-1 protease sequences contain networks of many pair correlations which...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435099/ https://www.ncbi.nlm.nih.gov/pubmed/28369521 http://dx.doi.org/10.1093/molbev/msx095 |