Cargando…

Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale

BACKGROUND: Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a la...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xihai, Li, Rui, Hippe, Daniel S, Hatsukami, Thomas S, Yuan, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435211/
https://www.ncbi.nlm.nih.gov/pubmed/28959486
http://dx.doi.org/10.1136/svn-2016-000053
_version_ 1783237194722312192
author Zhao, Xihai
Li, Rui
Hippe, Daniel S
Hatsukami, Thomas S
Yuan, Chun
author_facet Zhao, Xihai
Li, Rui
Hippe, Daniel S
Hatsukami, Thomas S
Yuan, Chun
author_sort Zhao, Xihai
collection PubMed
description BACKGROUND: Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population. OBJECTIVES: The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA). The relationship between carotid plaque features and cerebral infarcts, the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined. STUDY DESIGN: The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China. In this cross-sectional, non-randomised, observational, multicentre study, all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols. The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque. CONCLUSIONS: This is a cross-sectional, multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall. This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke. TRIAL REGISTRATION NUMBER: NCT02017756.
format Online
Article
Text
id pubmed-5435211
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-54352112017-09-28 Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale Zhao, Xihai Li, Rui Hippe, Daniel S Hatsukami, Thomas S Yuan, Chun Stroke Vasc Neurol Protocols BACKGROUND: Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population. OBJECTIVES: The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA). The relationship between carotid plaque features and cerebral infarcts, the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined. STUDY DESIGN: The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China. In this cross-sectional, non-randomised, observational, multicentre study, all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols. The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque. CONCLUSIONS: This is a cross-sectional, multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall. This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke. TRIAL REGISTRATION NUMBER: NCT02017756. BMJ Publishing Group 2017-02-24 /pmc/articles/PMC5435211/ /pubmed/28959486 http://dx.doi.org/10.1136/svn-2016-000053 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Protocols
Zhao, Xihai
Li, Rui
Hippe, Daniel S
Hatsukami, Thomas S
Yuan, Chun
Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title_full Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title_fullStr Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title_full_unstemmed Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title_short Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
title_sort chinese atherosclerosis risk evaluation (care ii) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in chinese patients with ischaemic cerebrovascular events—design and rationale
topic Protocols
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435211/
https://www.ncbi.nlm.nih.gov/pubmed/28959486
http://dx.doi.org/10.1136/svn-2016-000053
work_keys_str_mv AT zhaoxihai chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale
AT lirui chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale
AT hippedaniels chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale
AT hatsukamithomass chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale
AT yuanchun chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale
AT chineseatherosclerosisriskevaluationcareiistudyanovelcrosssectionalmulticentrestudyoftheprevalenceofhighriskatheroscleroticcarotidplaqueinchinesepatientswithischaemiccerebrovasculareventsdesignandrationale