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Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up
BACKGROUND: Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated. METHODS: A retrospective study of sixteen patients was undertak...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435341/ https://www.ncbi.nlm.nih.gov/pubmed/28545150 http://dx.doi.org/10.1371/journal.pone.0177835 |
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author | Zhu, Wei Ma, Qi Bian, Yanyan Zhuang, Qianyu Xia, Zenan Jin, Jin Weng, Xisheng |
author_facet | Zhu, Wei Ma, Qi Bian, Yanyan Zhuang, Qianyu Xia, Zenan Jin, Jin Weng, Xisheng |
author_sort | Zhu, Wei |
collection | PubMed |
description | BACKGROUND: Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated. METHODS: A retrospective study of sixteen patients was undertaken to evaluate treatment of tumors with joint arthroplasty and tumor resection. The bone metabolism index, hip/knee joint function, arthroplasty complications and symptoms were followed up for at least 12 months in each patient. RESULTS: All patients presented with neoplasms situated in the articular surface of the metaphysis, with 13 cases undergoing hip arthroplasty and 3 undergoing knee arthroplasty. Treatment of the tumors with joint arthroplasty and tumor resection significantly and rapidly ameliorate bone metabolism indexes in patients with TIO (p<0.01), with no identified tumor recurrence. The joint function evaluation score was improved in 15 patients (93.75%). Complications in these patients included post-operative pain, joint squeaking and secondary hyperparathyroidism. CONCLUSIONS: Joint arthroplasty that includes tumor-expanding resection appears to be a safe and appropriate method for the treatment of TIO patients with a neoplasm located in the metaphysis proximal to the articular surface. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. |
format | Online Article Text |
id | pubmed-5435341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54353412017-05-26 Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up Zhu, Wei Ma, Qi Bian, Yanyan Zhuang, Qianyu Xia, Zenan Jin, Jin Weng, Xisheng PLoS One Research Article BACKGROUND: Tumor-induced osteomalacia (TIO) may result in a better prognosis after complete resection of the causative neoplasm. However, tumors located proximal to the articular surface of the metaphysis remain largely uninvestigated. METHODS: A retrospective study of sixteen patients was undertaken to evaluate treatment of tumors with joint arthroplasty and tumor resection. The bone metabolism index, hip/knee joint function, arthroplasty complications and symptoms were followed up for at least 12 months in each patient. RESULTS: All patients presented with neoplasms situated in the articular surface of the metaphysis, with 13 cases undergoing hip arthroplasty and 3 undergoing knee arthroplasty. Treatment of the tumors with joint arthroplasty and tumor resection significantly and rapidly ameliorate bone metabolism indexes in patients with TIO (p<0.01), with no identified tumor recurrence. The joint function evaluation score was improved in 15 patients (93.75%). Complications in these patients included post-operative pain, joint squeaking and secondary hyperparathyroidism. CONCLUSIONS: Joint arthroplasty that includes tumor-expanding resection appears to be a safe and appropriate method for the treatment of TIO patients with a neoplasm located in the metaphysis proximal to the articular surface. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. Public Library of Science 2017-05-17 /pmc/articles/PMC5435341/ /pubmed/28545150 http://dx.doi.org/10.1371/journal.pone.0177835 Text en © 2017 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhu, Wei Ma, Qi Bian, Yanyan Zhuang, Qianyu Xia, Zenan Jin, Jin Weng, Xisheng Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title | Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title_full | Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title_fullStr | Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title_full_unstemmed | Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title_short | Total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: More than 1 year follow-up |
title_sort | total hip/knee arthroplasty in the treatment of tumor-induced osteomalacia patients: more than 1 year follow-up |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435341/ https://www.ncbi.nlm.nih.gov/pubmed/28545150 http://dx.doi.org/10.1371/journal.pone.0177835 |
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